Antiperspirant effects and mechanism investigation of Mulisan decoction in rats based on plasma metabolomics

Mulisan decoction (MLS) is a classic formula of traditional Chinese medicine for treating hyperhidrosis. The mechanism remains unclear.To investigate the antiperspirant effect and underlying mechanisms of MLS.Fifty rats were divided into control, model, and three doses of MLS intervention groups (Rats treated with MLS presented a significant decrease in sweat point numbers (13.5%), increase in body weight (13.2%), and promotion in the balance of Th1/Th2 cytokine ratioMLS demonstrated a good antiperspirant effect and metabolism improvement. These findings inspire more clinical study validation on immune improvement and antiperspirant effect.