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Epigenetic targeting of cancer stem cells by polyphenols (cancer stem cells targeting)
- Source :
- Phytotherapy Research. 35:3649-3664
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Epigenetic alterations are one of the main factors that disrupt the expression of genes and consequently, they have an important role in the carcinogenicity and the progression of different cancers. Cancer stem cells (CSCs) are accountable for the recurrence, metastasis, and therapeutic failure of cancer. The noticeable and specific pathways in CSCs can be organized by epigenetic mechanisms such as DNA methylation, chromatin remodeling, regulatory RNAs, among others. Since epigenetics modifications can be changed and reversed, it is a possible tool for cancer control and treatment. Epigenetic therapies against CSCs are emerging as a very new strategy with a good future expectation to treat cancer patients. Phenolic compounds are a vast group of substances with anticarcinogenic functions, antiinflammatory, and antioxidative activities. It seems these characteristics are related to neutralizing CSCs development, their microenvironment, and metabolism through epigenetic mechanisms. In the current work, the types of epigenetic changes known in these cells are introduced. In addition, some studies about the use of polyphenols acting through a variety of epigenetic mechanisms to counteract these cells will be reviewed. The reported results seem to indicate that the use of these phenolic compounds may be useful for CSCs defeat.
- Subjects :
- Pharmacology
0303 health sciences
030302 biochemistry & molecular biology
Polyphenols
Cancer
DNA Methylation
Biology
medicine.disease
Chromatin remodeling
Epigenesis, Genetic
Metastasis
03 medical and health sciences
0302 clinical medicine
Cancer stem cell
Neoplasms
030220 oncology & carcinogenesis
DNA methylation
Neoplastic Stem Cells
Tumor Microenvironment
medicine
Cancer research
Humans
Epigenetics
Gene
Carcinogen
Subjects
Details
- ISSN :
- 10991573 and 0951418X
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Phytotherapy Research
- Accession number :
- edsair.doi.dedup.....268488cabb7fcfb68272e29688127ff9
- Full Text :
- https://doi.org/10.1002/ptr.7059