Association of Target Organ Damage With 24-Hour Systolic and Diastolic Blood Pressure Levels and Hypertension Subtypes in Untreated Chinese

The association of target organ damage with 24-hour systolic and diastolic blood pressure levels and ambulatory hypertension subtypes has not yet been examined in untreated Chinese patients. We measured left ventricular mass index by echocardiography (n=619), the urinary albumin:creatinine ratio (n=1047), and aortic pulse wave velocity by tonometry (n=1013) in 1047 untreated subjects (mean age, 50.6 years; 48.9% women). Normotension was a 24-hour systolic/diastolic blood pressure P ≤0.003) left ventricular mass index (+4.31 g/m 2 ), urinary albumin:creatinine ratio (+1.63 mg/mmol), and pulse wave velocity (+0.76 m/s); and isolated diastolic hypertension was associated with similar left ventricular mass index and pulse wave velocity ( P ≥0.39), but higher urinary albumin:creatinine ratio (+1.24 mg/mmol; P =0.002). In younger participants (2 ( P =0.009/0.79) for left ventricular mass index, +1.15/+1.14 mg/mmol ( P =0.02/0.04) for the urinary albumin:creatinine ratio, and +0.54/–0.05 m/s ( P 2 ( P =0.045/0.88), +1.23/+1.05 mg/mmol ( P =0.002/0.54), and +0.76/–0.49 m/s ( P