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Epilepsy, antiepileptic drugs, and the risk of major cardiovascular events
- Source :
- Epilepsia. 62:1604-1616
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- OBJECTIVE This study was undertaken to determine whether epilepsy and antiepileptic drugs (including enzyme-inducing and non-enzyme-inducing drugs) are associated with major cardiovascular events using population-level, routinely collected data. METHODS Using anonymized, routinely collected, health care data in Wales, UK, we performed a retrospective matched cohort study (2003-2017) of adults with epilepsy prescribed an antiepileptic drug. Controls were matched with replacement on age, gender, deprivation quintile, and year of entry into the study. Participants were followed to the end of the study for the occurrence of a major cardiovascular event, and survival models were constructed to compare the time to a major cardiovascular event (cardiac arrest, myocardial infarction, stroke, ischemic heart disease, clinically significant arrhythmia, thromboembolism, onset of heart failure, or a cardiovascular death) for individuals in the case group versus the control group. RESULTS There were 10 241 cases (mean age = 49.6 years, 52.2% male, mean follow-up = 6.1 years) matched to 35 145 controls. A total of 3180 (31.1%) cases received enzyme-inducing antiepileptic drugs, and 7061 (68.9%) received non-enzyme-inducing antiepileptic drugs. Cases had an increased risk of experiencing a major cardiovascular event compared to controls (adjusted hazard ratio = 1.58, 95% confidence interval [CI] = 1.51-1.63, p
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Adolescent
Population
Disease
Risk Assessment
Cohort Studies
Young Adult
03 medical and health sciences
Epilepsy
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
Myocardial infarction
education
Stroke
Survival analysis
Aged
Retrospective Studies
Aged, 80 and over
education.field_of_study
Wales
business.industry
Hazard ratio
Middle Aged
medicine.disease
Survival Analysis
United Kingdom
Treatment Outcome
030104 developmental biology
Neurology
Cardiovascular Diseases
Case-Control Studies
Enzyme Induction
Heart failure
Anticonvulsants
Female
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15281167 and 00139580
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Epilepsia
- Accession number :
- edsair.doi.dedup.....26a15915918026a882ca3ccdc8ca4919