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A controlled clinical trial comparing potent progestins, LNG‐IUS and dienogest, for the treatment of women with adenomyosis
- Source :
- Reproductive Medicine and Biology, Reproductive Medicine and Biology, Vol 20, Iss 4, Pp 427-434 (2021)
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Purpose To evaluate the efficacy of two progestins, levonorgestrel intrauterine system (LNG‐IUS) and dienogest (DNG), for adenomyosis. Methods This study enrolled 157 women with adenomyosis, randomized to either LNG‐IUS (n = 76) or DNG (n = 81) groups as a controlled clinical trial for 72 months. Participants were classified by three different localizations of adenomyosis: diffuse, focal, and extrinsic. VAS (Visual analog scale) score, days, and amount of uterine bleeding were assessed. Uterine volume or bone mineral density (BMD) were measured by three‐dimensional ultrasonography or dual‐energy X‐ray absorptiometry. Results LNG‐IUS and DNG comparably reduced pain scores in patients with adenomyosis. With regard to pain control, DNG offered greater efficacy than LNG‐IUS in 3 months of treatment. In all types of adenomyosis, the days of bleeding after 12 months with DNG were significantly decreased compared to those with LNG‐IUS. The decrease of whole uterine body was transient in any subtypes. A comparable decrease in BMD due to age‐related changes in both groups was observed. Conclusions LNG‐IUS and DNG could be useful for long‐term management of adenomyosis. In terms of durations of uterine bleeding, DNG was superior to LNG‐IUS for 6 years.<br />We described the efficacy of two progestins, levonorgestrel intrauterine system (LNG‐IUS) and dienogest (DNG) in the treatment of adenomyosis as a first controlled clinical trial. Patients were classified by three different localizations of adenomyosis: diffuse, focal, and extrinsic. DNG proved superior to LNG‐IUS in terms of the duration of uterine bleeding.
- Subjects :
- endocrine system
medicine.medical_specialty
QH471-489
Visual analogue scale
Urology
Diseases of the endocrine glands. Clinical endocrinology
chemistry.chemical_compound
medicine
Levonorgestrel
Adenomyosis
Bone mineral
business.industry
Reproduction
Pelvic pain
uterine bleeding
Uterine bleeding
pelvic pain
Original Articles
Cell Biology
RC648-665
medicine.disease
Clinical trial
LNG‐IUS
Reproductive Medicine
Dienogest
chemistry
adenomyosis
dienogest
Original Article
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 14470578 and 14455781
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Reproductive Medicine and Biology
- Accession number :
- edsair.doi.dedup.....26adf2b06200c8a86b7db983ea313419