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The role of idiotype vaccines in the treatment of human B-cell malignancies
- Source :
- Expert Review of Vaccines. 3:163-170
- Publication Year :
- 2004
- Publisher :
- Informa UK Limited, 2004.
-
Abstract
- Twelve years after the first formal demonstration that it is possible to vaccinate a cancer patient against an antigen derived from his/her own tumor, idiotype vaccines are now well into Phase III clinical trials for the treatment of follicular lymphoma. Meanwhile, their potential has also begun to be explored in other non-Hodgkin's lymphoma settings, such as that of mantle cell lymphoma. Another well known field of potential application for idiotype vaccines is that of multiple myeloma. However, the currently available results, even with the advent of dendritic cells, seem to be less promising than those obtained in lymphoma, to such an extent that idiotype vaccines are currently tested in multiple myeloma patients in the context of more aggressive therapeutic strategies.
- Subjects :
- Idiotype
Lymphoma, B-Cell
Immunology
Follicular lymphoma
Context (language use)
Lymphoma, Mantle-Cell
Biology
Cancer Vaccines
Immunoglobulin Idiotypes
Antigen
immune system diseases
Cancer Vaccines/immunology
hemic and lymphatic diseases
Drug Discovery
Vaccines, DNA
medicine
Humans
Lymphoma, Follicular
Multiple myeloma
Pharmacology
Lymphoma, Non-Hodgkin
Cancer
medicine.disease
Antibodies, Anti-Idiotypic
Lymphoma
Dendritic Cells, Follicular/immunology
Molecular Medicine
Mantle cell lymphoma
Multiple Myeloma
Dendritic Cells, Follicular
Subjects
Details
- ISSN :
- 17448395 and 14760584
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Expert Review of Vaccines
- Accession number :
- edsair.doi.dedup.....26de7b9e42c7b520a996a2fadc232030