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The vaccination threshold for SARS-CoV-2 depends on the indoor setting and room ventilation
- Source :
- BMC Infectious Diseases, BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-9 (2021)
- Publication Year :
- 2021
- Publisher :
- BioMed Central, 2021.
-
Abstract
- Background Effective vaccines are now available for SARS-CoV-2 in the 2nd year of the COVID-19 pandemic, but there remains significant uncertainty surrounding the necessary vaccination rate to safely lift occupancy controls in public buildings and return to pre-pandemic norms. The aim of this paper is to estimate setting-specific vaccination thresholds for SARS-CoV-2 to prevent sustained community transmission using classical principles of airborne contagion modeling. We calculated the airborne infection risk in three settings, a classroom, prison cell block, and restaurant, at typical ventilation rates, and then the expected number of infections resulting from this risk at varying percentages of occupant immunity. Results We estimate the setting-specific immunity threshold for control of wild-type SARS-CoV-2 to range from a low of 40% for a mechanically ventilation classroom to a high of 85% for a naturally ventilated restaurant. Conclusions If vaccination rates are limited to a theoretical minimum of approximately two-thirds of the population, enhanced ventilation above minimum standards for acceptable air quality is needed to reduce the frequency and severity of SARS-CoV-2 superspreading events in high-risk indoor environments.
- Subjects :
- Infection risk
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Population
Infectious and parasitic diseases
RC109-216
Airborne transmission
law.invention
law
Air Pollution
Environmental health
Pandemic
Medicine
Humans
SARS-CoV-2
Vaccination
Ventilation
Pandemics
Air Pollution, Indoor
COVID-19
Indoor
education
Air quality index
education.field_of_study
business.industry
Research
Infectious Diseases
Transmission (mechanics)
Ventilation (architecture)
business
Subjects
Details
- Language :
- English
- ISSN :
- 14712334
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- BMC Infectious Diseases
- Accession number :
- edsair.doi.dedup.....275763f5ac78b526e9de49456766b0a5