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Panaxatriol saponin ameliorates myocardial infarction-induced cardiac fibrosis by targeting Keap1/Nrf2 to regulate oxidative stress and inhibit cardiac-fibroblast activation and proliferation
- Source :
- Free Radical Biology and Medicine. 190:264-275
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Cardiac fibrosis is a common precursor of ventricular dysfunction and heart failure. We investigated the role of oxidative stress in myocardial fibrosis and the protective effect of panaxatriol saponin (PTS) against myocardial infarction (MI)-induced cardiac fibrosis and explored the underlying mechanisms. In vitro, cell viability was tested using a cell counting kit. The reactive oxygen species (ROS) levels including hydrogen peroxide (H
- Subjects :
- Kelch-Like ECH-Associated Protein 1
Ginsenosides
NF-E2-Related Factor 2
Superoxide Dismutase
Myocardial Infarction
Hydrogen Peroxide
Fibroblasts
Saponins
Fibrosis
Biochemistry
Rats
Molecular Docking Simulation
Oxidative Stress
Physiology (medical)
Animals
Reactive Oxygen Species
Cell Proliferation
Signal Transduction
Subjects
Details
- ISSN :
- 08915849
- Volume :
- 190
- Database :
- OpenAIRE
- Journal :
- Free Radical Biology and Medicine
- Accession number :
- edsair.doi.dedup.....275d8768c1ccaf9bb6dd96ecc5d13e08