Supplementary Table 1 and Supplementary Figures 1-3 from Combinatorial Inhibition of Focal Adhesion Kinase and BCL-2 Enhances Antileukemia Activity of Venetoclax in Acute Myeloid Leukemia

Supplemental Table 1. Characteristics of AML patient samples used for the study. Supplemental Figure 1. PDX cells (mixed cells of the bone marrow and spleen), cultured alone or co-cultured with MSCs, were treated with VS-4718, ABT-199, or both. Annexin V/7AAD positivity was determined in human CD45+ cells by flow cytometry. COCX, co-cultured with MSCs. Supplemental Figure 2. Spleen sizes of the first, second, and fourth mice that died in the combination treatment group.