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Common DNA methylation dynamics in endometriod adenocarcinoma and glioblastoma suggest universal epigenomic alterations in tumorigenesis
- Source :
- Communications Biology, Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
- Publication Year :
- 2020
-
Abstract
- Trends in altered DNA methylation have been defined across human cancers, revealing global loss of methylation (hypomethylation) and focal gain of methylation (hypermethylation) as frequent cancer hallmarks. Although many cancers share these trends, little is known about the specific differences in DNA methylation changes across cancer types, particularly outside of promoters. Here, we present a comprehensive comparison of DNA methylation changes between two distinct cancers, endometrioid adenocarcinoma (EAC) and glioblastoma multiforme (GBM), to elucidate common rules of methylation dysregulation and changes unique to cancers derived from specific cells. Both cancers exhibit significant changes in methylation over regulatory elements. Notably, hypermethylated enhancers within EAC samples contain several transcription factor binding site clusters with enriched disease ontology terms highlighting uterine function, while hypermethylated enhancers in GBM are found to overlap active enhancer marks in adult brain. These findings suggest that loss of original cellular identity may be a shared step in tumorigenesis.<br />Jennifer Karlow et al. characterize the DNA methylation changes in two unrelated cancer types. They find that both cancers show methylation changes in regulatory regions corresponding to the cancer’s tissue of origin, suggesting that loss of cellular identity may be an important step in tumorigeneses shared across cancers.
- Subjects :
- Epigenomics
QH301-705.5
Carcinogenesis
Medicine (miscellaneous)
Biology
medicine.disease_cause
General Biochemistry, Genetics and Molecular Biology
Article
Epigenesis, Genetic
Histones
03 medical and health sciences
0302 clinical medicine
Endometrial cancer
medicine
Tumor Cells, Cultured
Humans
Biology (General)
skin and connective tissue diseases
030304 developmental biology
0303 health sciences
Binding Sites
DNA methylation
Gene Expression Profiling
Cancer
Promoter
Methylation
medicine.disease
Endometrial Neoplasms
DNA binding site
Gene Expression Regulation, Neoplastic
CNS cancer
030220 oncology & carcinogenesis
Cancer research
Adenocarcinoma
Female
sense organs
General Agricultural and Biological Sciences
Glioblastoma
Carcinoma, Endometrioid
Transcription Factors
Subjects
Details
- ISSN :
- 23993642
- Volume :
- 4
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Communications biology
- Accession number :
- edsair.doi.dedup.....278202564b214294b2694b6874002e84