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Composition and functional role of the mucus layers in the intestine
- Source :
- Cellular and Molecular Life Sciences; Vol 68
- Publication Year :
- 2011
-
Abstract
- In discussions on intestinal protection, the protective capacity of mucus has not been very much considered. The progress in the last years in understanding the molecular nature of mucins, the main building blocks of mucus, has, however, changed this. The intestinal enterocytes have their apical surfaces covered by transmembrane mucins and the whole intestinal surface is further covered by mucus, built around the gel-forming mucin MUC2. The mucus of the small intestine has only one layer, whereas the large intestine has a two-layered mucus where the inner, attached layer has a protective function for the intestine, as it is impermeable to the luminal bacteria.
- Subjects :
- Functional role
Models, Molecular
Protective capacity
Microbiology
03 medical and health sciences
Cellular and Molecular Neuroscience
fluids and secretions
0302 clinical medicine
medicine
Animals
Humans
Large intestine
Intestinal Mucosa
Molecular Biology
Immunity, Mucosal
030304 developmental biology
Pharmacology
0303 health sciences
Chemistry
Mucin
Mucins
Cell Biology
respiratory system
Mucus
Small intestine
Transmembrane protein
Cell biology
Intestines
medicine.anatomical_structure
Enterocytes
Mucosal immunology
030220 oncology & carcinogenesis
Molecular Medicine
Subjects
Details
- ISSN :
- 14209071
- Volume :
- 68
- Issue :
- 22
- Database :
- OpenAIRE
- Journal :
- Cellular and molecular life sciences : CMLS
- Accession number :
- edsair.doi.dedup.....27aab2ff60f92e77466c0df8b8c2e7b0