Back to Search
Start Over
Consensus acute kidney injury criteria integration identifies children at risk for long-term kidney dysfunction after multiple organ dysfunction syndrome
- Source :
- Pediatr Nephrol
- Publication Year :
- 2020
-
Abstract
- BACKGROUND: The consensus definition of acute kidney injury (AKI) has evolved since developing the original multiple organ dysfunction syndrome (MODS) definitions. Whether or not risk for adverse short- and long-term outcomes can be identified using the refined AKI criteria in the setting of MODS has not been studied. We hypothesize that incorporation of kidney disease: improving global outcome (KDIGO) AKI criteria into existing MODS definitions will have a higher association with major adverse kidney events at 30 days (MAKE30) and will increase the number of patients with MODS. METHODS: Post-hoc analysis of 410 children admitted to a tertiary care pediatric intensive care unit (PICU). MODS was defined using two existing criteria (Goldstein and Proulx) during the first 7 days following ICU admission and then modified by replacement of the kidney injury criteria using the KDIGO AKI definitions (G’ and P’). RESULTS: MAKE30 occurred in 65 of 410 (16%) children. After substituting KDIGO kidney injury criteria, identification of MAKE30 increased from 46 children (71%) to 53 (82%) and 29 children (45%) to 43 (66%) for the Goldstein and Proulx criteria, respectively. Additionally, identification of MODS increased from 194 (47%) by Goldstein to 224 (55%) by G’ and 95 children (23%) by Proulx to 132 (32%) by P’. CONCLUSION: Substituting KDIGO AKI criteria into existing MODS criteria increases the sensitivity for major adverse kidney events as well as the identification of MODS, improving the detection of children at risk for long-term adverse renal outcomes.
- Subjects :
- Nephrology
medicine.medical_specialty
Consensus
Multiple Organ Failure
030232 urology & nephrology
030204 cardiovascular system & hematology
Kidney
Article
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Post-hoc analysis
Medicine
Humans
Child
Retrospective Studies
Pediatric intensive care unit
business.industry
Kidney dysfunction
Acute kidney injury
Acute Kidney Injury
medicine.disease
medicine.anatomical_structure
Pediatrics, Perinatology and Child Health
Emergency medicine
business
Multiple organ dysfunction syndrome
Kidney disease
Subjects
Details
- ISSN :
- 1432198X
- Volume :
- 36
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Pediatric nephrology (Berlin, Germany)
- Accession number :
- edsair.doi.dedup.....27f1695761a99c1de69e720186b983bf