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White matter microstructure in patients with obsessive-compulsive disorder
- Source :
- Journal of psychiatryneuroscience : JPN. 36(1)
- Publication Year :
- 2010
-
Abstract
- Background: Previous diffusion tensor imaging (DTI) studies in patients with obsessive-compulsive disorder (OCD) have reported inconsistent findings, and it is not known whether observed findings are related to abnormalities in axonal structure or myelination. Methods: In this DTI study, we investigated fractional anisotropy, as well as axial and radial diffusivity, in 21 patients with OCD and 29 healthy controls. Results: We found decreased fractional anisotropy in the body of the corpus callosum in the OCD group, which was underpinned by increased radial diffusivity. Limitations: The cross-sectional design was the main limitation. Conclusion: Our findings of increased radial diffusivity provide preliminary evidence for abnormal myelination in patients with OCD.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Obsessive-Compulsive Disorder
Corpus callosum
behavioral disciplines and activities
Nerve Fibers, Myelinated
Corpus Callosum
White matter
Nuclear magnetic resonance
Obsessive compulsive
mental disorders
Fractional anisotropy
Medicine
Humans
Pharmacology (medical)
In patient
Biological Psychiatry
business.industry
Radial diffusivity
Brain
medicine.disease
Research Papers
humanities
Psychiatry and Mental health
medicine.anatomical_structure
Diffusion Tensor Imaging
nervous system
Anisotropy
Female
business
Anxiety disorder
Diffusion MRI
Subjects
Details
- ISSN :
- 14882434
- Volume :
- 36
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of psychiatryneuroscience : JPN
- Accession number :
- edsair.doi.dedup.....27f803fbb1bc318a7509313fa2fbf9c0