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Diet impacts triple-negative breast cancer growth, metastatic potential, chemotherapy responsiveness, and doxorubicin-mediated cardiac dysfunction
Diet impacts triple-negative breast cancer growth, metastatic potential, chemotherapy responsiveness, and doxorubicin-mediated cardiac dysfunction
- Source :
- Physiological reports. 10(8)
- Publication Year :
- 2022
-
Abstract
- Anthracyclines are standard-of-care chemotherapy for the treatment of triple-negative breast cancer (TNBC). However, high anthracyclines cumulative doses increase heart failure risk. Designing therapeutic strategies that ameliorate cardiac toxicities without compromising oncologic efficacy are important to improve TNBC outcomes and survivorship. The purpose of this study was to determine the impact of diet on TNBC chemotherapeutic responsiveness and development of chemotherapy-induced cardiac damage. Female BALB/c mice fed a control, Western, Mediterranean, or Western + fish oil diet were injected with 1 × 10
Details
- ISSN :
- 2051817X
- Volume :
- 10
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Physiological reports
- Accession number :
- edsair.doi.dedup.....27f9f78db524fa08a866d37ca1ab6da3