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Diet impacts triple-negative breast cancer growth, metastatic potential, chemotherapy responsiveness, and doxorubicin-mediated cardiac dysfunction

Diet impacts triple-negative breast cancer growth, metastatic potential, chemotherapy responsiveness, and doxorubicin-mediated cardiac dysfunction

Authors :
Manuel U. Ramirez
Kenysha Y. J. Clear
Zipporah Cornelius
Alaa Bawaneh
Yismeilin R. Feliz‐Mosquea
Adam S. Wilson
Alistaire D. Ruggiero
Nildris Cruz‐Diaz
Lihong Shi
Bethany A. Kerr
David R. Soto‐Pantoja
Katherine L. Cook
Source :
Physiological reports. 10(8)
Publication Year :
2022

Abstract

Anthracyclines are standard-of-care chemotherapy for the treatment of triple-negative breast cancer (TNBC). However, high anthracyclines cumulative doses increase heart failure risk. Designing therapeutic strategies that ameliorate cardiac toxicities without compromising oncologic efficacy are important to improve TNBC outcomes and survivorship. The purpose of this study was to determine the impact of diet on TNBC chemotherapeutic responsiveness and development of chemotherapy-induced cardiac damage. Female BALB/c mice fed a control, Western, Mediterranean, or Western + fish oil diet were injected with 1 × 10

Details

ISSN :
2051817X
Volume :
10
Issue :
8
Database :
OpenAIRE
Journal :
Physiological reports
Accession number :
edsair.doi.dedup.....27f9f78db524fa08a866d37ca1ab6da3