A Comprehensive Expression Analysis of Mucins in Appendiceal Carcinoma in a Multicenter Study: MUC3 Is a Novel Prognostic Factor

Authors :: Hideki Tsuji
Satoru Kawai
Toshiyuki Arai
Koutarou Hattori
Yukie Tashiro
Takashi Hiromatsu
Michihiko Narita
Shingo Kuze
Yasuhiro Kurumiya
Iwao Kitazono
Karine Rousseau
Hitoshi Kubota
Masahiko Osako
Eiji Sasaki
Norihiro Yuasa
Osamu Okochi
Masaki Sakamoto
Masahiko Fujino
Naomi Konishi
Hiroshi Hasagawa
Hiroaki Shibahara
Hiroshi Shirahama
Akinobu Kondo
Shinji Kondo
Michiyo Higashi
Yoshichika Okamoto
Suguru Yonezawa
Tatsuyoshi Yamamoto
Hideaki Suzuki
Surinder K. Batra
Seiya Yokoyama
Yu Sakai
Kazuhisa Shirai
Takehito Kato
Source :: PLoS ONE, PLoS ONE, Vol 9, Iss 12, p e115613 (2014)
Publication Year :: 2014
Publisher :: Public Library of Science, 2014.
Abstract: Background Mucins are implicated in survival in various cancers, but there have been no report addressed on survival in appendiceal carcinoma, an uncommon disease with different clinical and pathological features from those of other colon cancers. We aimed to investigate the clinical implications of expression of mucins in appendiceal carcinoma. Methods Expression profiles of MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC6, MUC16 and MUC17 in cancer tissue were examined by immunohistochemistry in 108 cases of surgically resected appendiceal carcinoma. Results The following relationships of mucins with clinicopathologic factors were identified: MUC1 with positive lymphatic invasion (p = 0.036); MUC2 with histological type (mucinous carcinoma, p

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