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Are older patients with non-small cell lung cancer receiving optimal care? A population-based study
- Publication Year :
- 2022
- Publisher :
- Umeå universitet, Onkologi, 2022.
-
Abstract
- Background Results from studies addressing age-related patterns of cancer care have found evidence of unjustified differences in management between younger and older patients. Methods We examined associations between age and clinical presentation, management and mortality in patients diagnosed with non-small cell lung cancer (NSCLC) between 2002 and 2016. Analyses were adjusted for comorbidity and other factors that may have affected management decisions and outcomes. Results The study population encompassed 40,026 patients with NSCLC. Stage at diagnosis did not differ between age groups = 85 years. The use of stereotactic body radiotherapy (SBRT) increased with age (= 85 years 35.8%). In patients with stage IIIA disease and PS 0-2, concurrent chemoradiotherapy was more common in younger patients (= 85 years 2.2%). In stage IA-IIIA disease, no major differences in treatment-related mortality was observed. In stage IIIB-IV and PS 0-2, chemotherapy was more common in patients = 85 years received treatment. In stage IA-IIIA, overall and cause-specific survival decreased with increasing age. No age-differences in survival were observed in patients with stage IIIB-IV NSCLC. Conclusion Treatments were readily given to older patients with metastatic disease, but to a lesser degree to those with early stage disease. Significant differences in cause specific survival were observed in early, but not late stage disease. Our findings underscore the importance of individualized assessment of health status and life expectancy. Our results indicate that older patients with early stage lung cancer to a higher extent should be considered for curative treatment.
- Subjects :
- Oncology
medicine.medical_specialty
Lung Neoplasms
Population based
Nursing
Comorbidity
Radiosurgery
elderly
survival
Text mining
Older patients
Internal medicine
Carcinoma, Non-Small-Cell Lung
Epidemiology
medicine
Humans
Radiology, Nuclear Medicine and imaging
Lung cancer
Aged
Neoplasm Staging
Aged, 80 and over
Cancer och onkologi
business.industry
Omvårdnad
Cancer
Hematology
General Medicine
Chemoradiotherapy
medicine.disease
population-based
Population based study
age
Cancer and Oncology
epidemiology
Non small cell
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....284e4cb956f84646bdaa529f81bb2c7c