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Syncytial variant of nodular sclerosing Hodgkin lymphoma in children: A prognostic factor?
- Source :
- Pediatric hematology and oncology. 35(1)
- Publication Year :
- 2018
-
Abstract
- Nodular sclerosing Hodgkin lymphoma (HL) has an excellent prognosis in children. The syncytial variant (SV) of HL in adults represents a clinic pathologic entity with a worse outcome. We report the clinical features and the course of the disease of three children with refractory HL. The three patients with SV were analyzed in a retrospective multi-institutional study conducted in Israel in 51 children diagnosed with refractory or recurrent HL between 1997 and 2014. All the three children developed multiple recurrences soon after diagnosis. All three received at least three different chemotherapy combinations with autologous bone marrow transplantation for two patients, allogenic bone marrow transplantation in one, and immunotherapy in one. One patient died of disease, one is in complete response of the disease but developed a second metastatic malignancy, and one is alive without disease. This retrospective study shows that SV histology may be a prognostic factor for poor outcome in children diagnosed with HL.
- Subjects :
- Oncology
Adult
Male
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Disease
Malignancy
03 medical and health sciences
0302 clinical medicine
Refractory
Nodular sclerosis
Internal medicine
medicine
Humans
Child
Bone Marrow Transplantation
Retrospective Studies
business.industry
Retrospective cohort study
Histology
Hematology
Immunotherapy
medicine.disease
Allografts
Hodgkin Disease
030220 oncology & carcinogenesis
Child, Preschool
Pediatrics, Perinatology and Child Health
Hodgkin lymphoma
Female
business
030215 immunology
Subjects
Details
- ISSN :
- 15210669
- Volume :
- 35
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Pediatric hematology and oncology
- Accession number :
- edsair.doi.dedup.....28518091978b62231dde02cfc96b2930