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Human Plasmodium knowlesi infection in Ranong province, southwestern border of Thailand
- Source :
- Malaria Journal, Malaria Journal, Vol 11, Iss 1, p 36 (2012)
- Publisher :
- Springer Nature
-
Abstract
- Background Plasmodium knowlesi, a simian malaria parasite, has been reported in humans in many Southeast Asian countries. In Thailand, most of the limited numbers of cases reported so far were from areas near neighbouring countries, including Myanmar. Methods Blood samples collected from 171 Thai and 248 Myanmese patients attending a malaria clinic in Ranong province, Thailand, located near the Myanmar border were investigated for P. knowlesi using nested PCR assays. Positive samples were also investigated by PCR for Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae and Plasmodium ovale, and were confirmed by sequencing the gene encoding the circumsporozoite protein (csp). Results Two samples, one obtained from a Thai and the other a Myanmese, were positive for P. knowlesi only. Nucleotide sequences of the csp gene derived from these two patients were identical and phylogenetically indistinguishable from other P. knowlesi sequences derived from monkeys and humans. Both patients worked in Koh Song, located in the Kawthoung district of Myanmar, which borders Thailand. Conclusion This study indicates that transmission of P. knowlesi is occurring in the Ranong province of Thailand or the Kawthoung district of Myanmar. Further studies are required to assess the incidence of knowlesi malaria and whether macaques in these areas are the source of the infections.
- Subjects :
- Adult
Male
lcsh:Arctic medicine. Tropical medicine
Genotype
lcsh:RC955-962
Plasmodium vivax
Molecular Sequence Data
Protozoan Proteins
Sequence Homology
Plasmodium malariae
Myanmar
Circumsporozoite protein
Southeast asian
Plasmodium knowlesi
Polymerase Chain Reaction
lcsh:Infectious and parasitic diseases
parasitic diseases
medicine
Animals
Cluster Analysis
Humans
lcsh:RC109-216
Phylogeny
Molecular Epidemiology
biology
Research
fungi
Plasmodium falciparum
Sequence Analysis, DNA
DNA, Protozoan
Middle Aged
biology.organism_classification
Plasmodium ovale
medicine.disease
Thailand
Virology
Malaria
Blood
Infectious Diseases
Parasitology
Subjects
Details
- Language :
- English
- ISSN :
- 14752875
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Malaria Journal
- Accession number :
- edsair.doi.dedup.....28595838ff37835311bdd95b0a71da3b
- Full Text :
- https://doi.org/10.1186/1475-2875-11-36