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Nestin expression during mouse eye and lens development
- Source :
- Mechanisms of Development. 94(1-2):287-291
- Publication Year :
- 2000
- Publisher :
- Elsevier BV, 2000.
-
Abstract
- Nestin is an intermediate filament protein, which is expressed predominantly in the developing central nervous system and skeletal muscles. In situ hybridization revealed that mouse nestin mRNA is in the optic stalk at 9.0 days post coitus (dpc) and in the lens vesicle at 10.0 dpc. From 14.5 dpc onward, nestin transcripts appear in lens fibers and neuroretina. Immunohistochemistry showed that nestin protein appears in the optic stalk at 9.5 dpc and in the posterior lens epithelium at 10.5 dpc. By 12.5 dpc, it is found in the lens, neuroretina, and optic stalk as well as in developing extrinsic ocular muscle, and it localizes in lens epithelium, optic disc, and optic nerve from 14.5 dpc to postnatal day 1. In adult eye, nestin protein appears in the optic nerve.
- Subjects :
- Embryology
genetic structures
Molecular Sequence Data
Nerve Tissue Proteins
In situ hybridization
Biology
Eye
Nestin
Mice
Intermediate Filament Proteins
Lens, Crystalline
medicine
Animals
Optic stalk
RNA, Messenger
reproductive and urinary physiology
Gene Expression Regulation, Developmental
Anatomy
eye diseases
Lens Fiber
Cell biology
medicine.anatomical_structure
Lens (anatomy)
embryonic structures
Optic nerve
Eye development
sense organs
Optic disc
Developmental Biology
Subjects
Details
- ISSN :
- 09254773
- Volume :
- 94
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Mechanisms of Development
- Accession number :
- edsair.doi.dedup.....285f78c0ac16a2b6694ddbdf880f31d3
- Full Text :
- https://doi.org/10.1016/s0925-4773(00)00301-4