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A Brazilian pulp and paper mill effluent disrupts energy metabolism in immature rat testis and alters Sertoli cell secretion and mitochondrial activity
- Source :
- Animal Reproduction, Animal Reproduction, Volume: 17, Issue: 2, Article number: e20190116, Published: 03 JUL 2020
- Publication Year :
- 2020
-
Abstract
- Our objective was to investigate whether the pulp and paper mill industry effluent could affect the testis and Sertoli cells in a fast exposure period. For this, the present study was carried out in immature rats at 10-day-old. Testis treated in vitro with 4% effluent for 1 h presented changes in energy metabolism in terms of a decrease in lactate content and glucose uptake. Elevation in GSH content, as an antioxidant defense mechanism, was also detected. Sertoli cells treated with 4% effluent for 1 hour showed alterations in the mitochondrial metabolism that favor the decoupling of oxidative phosphorylation and the generation of oxygen reactive species and also a time and concentration-dependent delay secretion of acidic vesicles. Our results showed that pollutants present in the pulp and paper mill effluents, in a short time of exposure, are capable of inducing alterations in important metabolic functions in the testis and in Sertoli cells that are crucial for the correct progression of spermatogenesis and fertility.
- Subjects :
- Sertoli
Glucose uptake
Oxidative phosphorylation
testis
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
medicine
Secretion
lactate
030219 obstetrics & reproductive medicine
General Veterinary
0402 animal and dairy science
04 agricultural and veterinary sciences
Metabolism
Glutathione
Sertoli cell
040201 dairy & animal science
Cell biology
secretion
medicine.anatomical_structure
chemistry
Pulp (tooth)
Animal Science and Zoology
Original Article
effluent
Spermatogenesis
Subjects
Details
- ISSN :
- 19843143
- Volume :
- 17
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Animal reproduction
- Accession number :
- edsair.doi.dedup.....2865e0eb0e4e708c9895ea7a8ac25578