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Cytokine-induced killer cells/dendritic cells-cytokine induced killer cells immunotherapy combined with chemotherapy for treatment of colorectal cancer in China: a meta-analysis of 29 trials involving 2,610 patients
- Source :
- Oncotarget
- Publication Year :
- 2017
- Publisher :
- Impact Journals, LLC, 2017.
-
Abstract
- // Lei Zhang 1 , Ying Mu 2 , Anqi Zhang 3 , Jiaping Xie 2 , Shuangfeng Chen 3 , Fang Xu 4 , Weihua Wang 3 , Yingxin Zhang 3 , Shaoda Ren 3 and Changhui Zhou 3 1 Institute of Hematopathy, Henan Provincial People’s Hospital, Zhengzhou, Henan Province, China 2 Department of Gastroenterology, Liaocheng People’s Hospital, Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong Province, China 3 Department of Central Laboratory, Liaocheng People’s Hospital, Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong Province, China 4 Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan Province, China Correspondence to: Changhui Zhou, email: zhouchanghui008@163.com Shaoda Ren, email: zslrsd@163.com Keywords: cytokine-induced killer cells, dendritic cells, colorectal cancer, immunotherapy, meta-analysis Received: November 23, 2016 Accepted: March 17, 2017 Published: March 29, 2017 ABSTRACT Purpose: To systematically evaluate the efficacy and safety of Cytokine-induced killer cells/dendritic cells-cytokine induced killer cells (CIK/DC-CIK) immunotherapy in treating advanced colorectal cancer (CRC) patients. Results: 29 trials including 2,610 CRC patients were evolved. Compared with chemotherapy alone, the combination of chemotherapy with CIK/DC-CIK immunotherapy significantly prolonged the overall survival rate (OS) and disease-free survival rate (DFS) (1–5 year OS, P 0.05). Materials and Methods: Clinical trials reporting response or safety of CIK/DC-CIK immunotherapy treating advanced CRC patients and published before September 2016 were searched in Cochrane Library, EMBASE, PubMed, Wanfang and CNKI database. Research quality and heterogeneity were evaluated before analysis. Pooled analyses were performed using random or fixed-effect models. Conclusions: The combination of CIK/DC-CIK immunotherapy and chemotherapy prolong CRC patients’ survival time, enhanced patients’ immune function and alleviates the adverse effects caused by chemotherapy.
- Subjects :
- 0301 basic medicine
Oncology
China
medicine.medical_specialty
Colorectal cancer
cytokine-induced killer cells
medicine.medical_treatment
colorectal cancer
Cochrane Library
Immunotherapy, Adoptive
Disease-Free Survival
03 medical and health sciences
0302 clinical medicine
Internal medicine
Humans
Medicine
Survival rate
Survival analysis
Chemotherapy
Cytokine-induced killer cell
business.industry
Dendritic Cells
Immunotherapy
Prognosis
medicine.disease
Combined Modality Therapy
Survival Analysis
meta-analysis
Clinical trial
030104 developmental biology
030220 oncology & carcinogenesis
Immunology
immunotherapy
Colorectal Neoplasms
business
Research Paper
Subjects
Details
- ISSN :
- 19492553
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Oncotarget
- Accession number :
- edsair.doi.dedup.....286c926d4beddf6c2054f7a7ce918f7d