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Residual risks of ischaemic stroke and systemic embolism among atrial fibrillation patients with anticoagulation: large-scale real-world data (F-CREATE project)
- Source :
- Heart (British Cardiac Society). 107(3)
- Publication Year :
- 2020
-
Abstract
- ObjectiveAmong patients with atrial fibrillation, the risks of ischaemic stroke and systemic embolism (IS/SE) are high even with effective anticoagulation. Using large-scale, real-world data from Japan, this study aims to clarify residual risks of IS/SE attributable to modifiable risk factors among patients with atrial fibrillation who are taking oral anticoagulants.MethodsThe study design we employed was a retrospective cohort. Health check-ups and insurance claims data of Japanese health insurance companies were accumulated from January 2005 to June 2017. We identified 11 848 participants with atrial fibrillation who were on oral anticoagulants during the study period. We set the modifiable risk factors as hypertension, diabetes and dyslipidaemia. A Cox proportional hazards model was used to obtain the effects of the risk factors for IS/SE.ResultsDuring an average of 3 years’ follow-up, 200 cases of IS/SE occurred (incidence rate 0.57 per 100 person-years). In multivariable analyses, older age (65–74 vs ConclusionAmong patients with atrial fibrillation on anticoagulant therapy, approximately one-third of the residual risks were estimated to be attributable to modifiable risk factors such as hypertension, diabetes and dyslipidaemia.
- Subjects :
- Male
medicine.medical_specialty
Embolism
030204 cardiovascular system & hematology
Risk Assessment
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Risk Factors
Diabetes mellitus
Ischaemic stroke
Atrial Fibrillation
medicine
Humans
030212 general & internal medicine
Stroke
Aged
Ischemic Stroke
Retrospective Studies
business.industry
Proportional hazards model
Anticoagulants
Atrial fibrillation
Retrospective cohort study
Systemic embolism
Middle Aged
medicine.disease
Residual risk
Emergency medicine
Female
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 1468201X
- Volume :
- 107
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Heart (British Cardiac Society)
- Accession number :
- edsair.doi.dedup.....287fcfe00b56572bd9a7212bda14b035