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Comparison of the effects of Mg–6Zn and Ti–3Al–2.5V alloys on TGF-β/TNF-α/VEGF/b-FGF in the healing of the intestinal tractin vivo
- Source :
- Biomedical Materials. 9:025011
- Publication Year :
- 2014
- Publisher :
- IOP Publishing, 2014.
-
Abstract
- To evaluate the different effects of Mg-6Zn alloy and Ti-3Al-2.5V alloy implants in intestinal tract healing, we compared these two different alloys with respect to their effect on a rat's intestinal tract, using serum magnesium, radiology, pathology and immunohistochemistry in vivo. It was found using the scanning electron microscope that the Mg-6Zn alloy began to degrade during the first week and that the Ti-3Al-2.5V alloy was non-degradable throughout the process. The Mg-6Zn alloy did not have an impact on serum magnesium. Superior to the Ti-3Al-2.5V alloy, the Mg-6Zn alloy enhanced the expression of transforming growth factor-β1 in healing tissue, and promoted the expression of both the vascular endothelial growth factor and the basic fibroblast growth factor, which helped angiogenesis and healing. The Mg-6Zn alloy reduced the expression of the tumor necrosis factor (TNF-α) at different stages and decreased inflammatory response, which may have been related to the zinc inhibiting TNF-α. In general, the Mg-6Zn alloy performed better than Ti-3Al-2.5V at promoting healing and reducing inflammation. The Mg-6Zn alloy may be a promising candidate for use in the pins of circular staplers for gastrointestinal reconstruction in medicine.
- Subjects :
- Male
Vascular Endothelial Growth Factor A
Pathology
medicine.medical_specialty
Materials science
Angiogenesis
Basic fibroblast growth factor
Biomedical Engineering
Biocompatible Materials
Bioengineering
Inflammation
Rats, Sprague-Dawley
Transforming Growth Factor beta1
Biomaterials
chemistry.chemical_compound
In vivo
Materials Testing
Alloys
medicine
Animals
Magnesium
Intestinal Mucosa
Titanium
Wound Healing
Tumor Necrosis Factor-alpha
technology, industry, and agriculture
Vanadium
equipment and supplies
Rats
Vascular endothelial growth factor
Zinc
chemistry
Microscopy, Electron, Scanning
Cancer research
Fibroblast Growth Factor 2
Tumor necrosis factor alpha
medicine.symptom
Wound healing
Aluminum
Transforming growth factor
Subjects
Details
- ISSN :
- 1748605X and 17486041
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Biomedical Materials
- Accession number :
- edsair.doi.dedup.....28816239f36cd87dcdfbff52a4a096b3