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Livestock-Associated and Non-Livestock-Associated Staphylococcus aureus Carriage in Humans is Associated with Pig Exposure in a Dose–Response Manner
Livestock-Associated and Non-Livestock-Associated Staphylococcus aureus Carriage in Humans is Associated with Pig Exposure in a Dose–Response Manner
- Source :
- Infection and Drug Resistance
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- Yanling Liu, Wenhui Li, Qian Dong, Yangqun Liu, Xiaohua Ye School of Public Health, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaCorrespondence: Yangqun Liu; Xiaohua YeSchool of Public Health, Guangdong Pharmaceutical University, 283# Jianghai Dadao, Haizhu District, Guangzhou, People’s Republic of ChinaTel +862034055355Email 136437677@qq.com; smalltomato@163.comBackground: The distinction between livestock-associated and human-associated methicillin-resistant Staphylococcus aureus (MRSA) has become more and more blurred. This study aimed to reveal the transmission risk of livestock-associated and non-livestock-associated S. aureus (including MRSA and multidrug-resistant S. aureus [MDRSA]) by occupational pig exposure.Methods: A total of 591 pig-exposed workers and 1178 non-exposed workers were enrolled in this study. All nasal S. aureus isolates were tested for antibiotic susceptibility and molecular characteristics. Logistic regression models were used to examine the dose–response relationships between occupational pig exposure and S. aureus carriage.Results: Pig-exposed workers had significantly higher carriage rates of MRSA (OR=6.29, 95% CI: 3.38∼ 11.68) and MDRSA (OR=3.17, 95% CI: 2.03∼ 4.96) than non-exposed workers. Notably, we found dose–response relationships between occupational pig exposure and MRSA or MDRSA carriage. Using genotypic and phenotypic markers for differentiating livestock-associated and non-livestock-associated S. aureus, we also revealed dose–response relationships occupational pig exposure and livestock-associated or non-livestock-associated S. aureus carriage.Conclusion: Our findings provide sufficient epidemiological evidence for revealing the high transmission risk of livestock-associated S. aureus and the low transmission risk of non-livestock-associated S. aureus by occupational pig exposure.Keywords: livestock, human, methicillin-resistant S. aureus, multidrug-resistant S. aureus, transmission
- Subjects :
- 0301 basic medicine
Veterinary medicine
medicine.medical_specialty
medicine.drug_class
030106 microbiology
Antibiotics
medicine.disease_cause
Logistic regression
law.invention
03 medical and health sciences
0302 clinical medicine
law
parasitic diseases
Genotype
Epidemiology
medicine
Pharmacology (medical)
human
030212 general & internal medicine
Original Research
methicillin-resistant S. aureus
Pharmacology
business.industry
transmission
livestock
Infectious Diseases
Carriage
Transmission (mechanics)
multidrug-resistant S. aureus
Infection and Drug Resistance
Staphylococcus aureus
Livestock
business
Subjects
Details
- ISSN :
- 11786973
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Infection and Drug Resistance
- Accession number :
- edsair.doi.dedup.....288f487426cdc57df49a1249b3c4634e
- Full Text :
- https://doi.org/10.2147/idr.s290655