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Lp(a)-Associated Oxidized Phospholipids in Healthy Black and White Participants in Relation to apo(a) Size, Age, and Family Structure

Authors :
Erdembileg Anuurad
Kyoungmi Kim
Kevin Truax
Wei Zhang
Nishant Prakash
Byambaa Enkhmaa
Lars Berglund
Source :
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 17 (2021), Journal of the American Heart Association, vol 10, iss 17
Publication Year :
2021

Abstract

Background Lp(a) (lipoprotein(a)) is the major lipoprotein carrier of oxidized phospholipids (OxPL) and this function mediates Lp(a) atherogenicity. However, the relationship between OxPL, Lp(a), and genetic and biological characteristics remains poorly understood. We assessed the relationship between Lp(a)‐bound OxPL, apolipoprotein(a) (apo(a)) size, age, and family structure in 2 racial groups. Methods and Results Healthy Black and White families were recruited from the general population (age: 6–74 years, n=267). OxPL and Lp(a) levels were assayed enzymatically; apo(a) isoform, LPA allele sizes, and allele‐specific Lp(a) levels were determined. Lp(a)‐OxPL levels did not differ significantly by racial and age groups. Lp(a)‐OxPL levels were associated with total plasma Lp(a) in all participants and in race‐specific analyses. Further, OxPL levels were significantly associated with allele‐specific Lp(a) levels carried by the smaller apo(a) size in all participants (β=0.33, P =0.0003) as well as separately for Black (β=0.50, P =0.0032) and White (β=0.26, P =0.0181) participants. A significant association of OxPL with allele‐specific Lp(a) levels for larger apo(a) sizes was seen only in Black participants (β=0.53, P =0.0076). In this group, Lp(a)‐OxPL levels were also heritable (h 2 =0.29, P =0.0235), resulting in a significant interracial difference in heritability between Black and White people ( P =0.0352). Conclusions Lp(a)‐OxPL levels were associated with allele‐specific Lp(a) level carried on smaller apo(a) sizes and among Black participants also for larger apo(a) sizes. The heritability estimates for Lp(a)‐bound OxPL differed by race.

Details

ISSN :
20479980
Volume :
10
Issue :
17
Database :
OpenAIRE
Journal :
Journal of the American Heart Association
Accession number :
edsair.doi.dedup.....28b2d9ce17cc471a5c2ee9be69dec735