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A preliminary report of vitamin D and calcium metabolism in older African Americans
- Source :
- Journal of the American Geriatrics Society. 41(6)
- Publication Year :
- 1993
-
Abstract
- Objective: To determine normal serum bone-related biochemical variables in older African-Americans. Design: A convenience sample of older African-Americans who had a health screening and blood testing for calciotropic hormones was compared with white Americans who were recruited at the end of the Systolic Hypertension in the Elderly Program (SHEP) study and were not on a thiazide diuretic. Setting: Community-dwelling African-Americans who participated in SHEP or who attended one of two mass health screenings. Participants: Thirty-two African-Americans aged 68–93 years and 43 white Americans aged 70–89 years. Measurements: Twenty-five hydroxyvitamin D (250HD), parathyroid hormone, osteocalcin, and calcitonin. Results: Serum 250HD levels in 38% of the African-American men and 38% of African-American women were less than 8 ng/mL compared with 22% of Caucasian men and 40% of Caucasian women. Serum parathyroid hormone (PTH) was above the normal range in 25% of men and 33% of women of African-American descent and 14% of Caucasian men and 30% of Caucasian women. Serum 25OHD was lower (P < 0.05) in individuals with a previous history of fracture. Serum albumin (P < 0.05), calcitonin (P < 0.05), and osteocalcin (P < 0.05), but not 25OHD, were lower in African-Americans (men and women) when compared with Caucasians (P < 0.05). Serum calcium corrected for albumin was higher in the African-Americans than in the Caucasians (P < 0.05). As previously reported in Caucasians, PTH was inversely related to log 25OHD in African-Americans. Serum osteocalcin was positively correlated to PTH in African-Americans, as previously reported in Caucasians. Log 25OHD correlated inversely with osteocalcin in African-Americans, but this was not seen in Caucasians. Conclusions: In this limited sample, hypovitaminosis D (as assessed by 25OHD level) with secondary hyperparathyroidism occurred frequently in elderly African-Americans. Osteocalcin, a measure of osteoblast activity, correlated with 25OHD and parathyroid hormone. Osteocalcin serum levels were lower in African-Americans than Caucasians, but serum calcium corrected for albumin was higher in the former compared to the latter.
- Subjects :
- Calcitonin
Male
medicine.medical_specialty
Systolic hypertension
Osteocalcin
Serum albumin
Parathyroid hormone
Black People
White People
Sex Factors
Reference Values
Internal medicine
medicine
Vitamin D and neurology
Humans
Aged
Calcium metabolism
Aged, 80 and over
biology
business.industry
Hydroxycholecalciferols
Hyperparathyroidism
medicine.disease
Alkaline Phosphatase
Vitamin D Deficiency
Health Surveys
Endocrinology
Parathyroid Hormone
biology.protein
Secondary hyperparathyroidism
Calcium
Female
Geriatrics and Gerontology
business
Subjects
Details
- ISSN :
- 00028614
- Volume :
- 41
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of the American Geriatrics Society
- Accession number :
- edsair.doi.dedup.....28b6b4ce7952745a253210a11ea18912