Back to Search
Start Over
Epstein–Barr virus nuclear antigen 3C interact with p73: Interplay between a viral oncoprotein and cellular tumor suppressor
- Source :
- Virology. 448:333-343
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- The p73 protein has structural and functional homology with the tumor suppressor p53, which plays an important role in cell cycle regulation, apoptosis, and DNA repair. The p73 locus encodes both a tumor suppressor (TAp73) and a putative oncogene (ΔNp73). p73 May play a significant role in p53-deficient lymphomas infected with Epstein–Barr virus (EBV). EBV produces an asymptomatic infection in the majority of the global population, but it is associated with several human B-cell malignancies. The EBV-encoded Epstein–Barr virus nuclear antigen 3C (EBNA3C) is thought to disrupt the cell cycle checkpoint by interacting directly with p53 family proteins. Doxorubicin, a commonly used chemotherapeutic agent, induces apoptosis through p53 and p73 signaling such that the lowΔNp73 level promotes the p73-mediated intrinsic pathway of apoptosis. In this report, we investigated the mechanism by which EBV infection counters p73α-induced apoptosis through EBNA3C.
- Subjects :
- Epstein-Barr Virus Infections
Herpesvirus 4, Human
DNA repair
Apoptosis
Biology
Virus
law.invention
Antigen
law
hemic and lymphatic diseases
Cell Line, Tumor
Virology
medicine
Humans
skin and connective tissue diseases
B-cell lymphoma
neoplasms
Antigens, Viral
B-Lymphocytes
Oncogene
Tumor Suppressor Proteins
Nuclear Proteins
Tumor Protein p73
Cell cycle
medicine.disease
DNA-Binding Proteins
Epstein-Barr Virus Nuclear Antigens
Doxorubicin
Cancer research
Suppressor
Protein Binding
Subjects
Details
- ISSN :
- 00426822
- Volume :
- 448
- Database :
- OpenAIRE
- Journal :
- Virology
- Accession number :
- edsair.doi.dedup.....28c8a0a9840c52fa7cb13f3db3b3bd9b
- Full Text :
- https://doi.org/10.1016/j.virol.2013.10.023