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Risk of recurrence after chemoradiotherapy identified by multimodal MRI and 18F-FDG-PET/CT in locally advanced cervical cancer
- Source :
- Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 176
- Publication Year :
- 2022
-
Abstract
- MRI, applying dynamic contrast-enhanced (DCE) and diffusion-weighted (DW) sequences, and 18F-fluorodeoxyglucose (18F-FDG) PET/CT provide information about tumor aggressiveness that is unexploited in treatment of locally advanced cervical cancer (LACC). We investigated the potential of a multimodal combination of imaging parameters for classifying patients according to their risk of recurrence.Eighty-two LACC patients with diagnostic MRI and FDG-PET/CT, treated with chemoradiotherapy, were collected. Thirty-eight patients with MRI only were included for validation of MRI results. Endpoints were survival (disease-free, cancer-specific, overall) and tumor control (local, locoregional, distant). KHF showed a stronger association with outcome than the single modality parameters. This association was confirmed in the validation cohort. Low HF identified low-risk patients with 95% precision. Based on the 50th SUV-percentile (SUVMultimodal combination of MR- and FDG-PET/CT-images improves classification of LACC patients compared to single modality images and clinical factors.
- Subjects :
- Uterine Cervical Neoplasms
Hematology
Chemoradiotherapy
Magnetic Resonance Imaging
Diffusion Magnetic Resonance Imaging
Oncology
Fluorodeoxyglucose F18
Positron Emission Tomography Computed Tomography
Positron-Emission Tomography
Humans
Radiology, Nuclear Medicine and imaging
Female
Radiopharmaceuticals
Tomography, X-Ray Computed
Subjects
Details
- ISSN :
- 18790887
- Volume :
- 176
- Database :
- OpenAIRE
- Journal :
- Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
- Accession number :
- edsair.doi.dedup.....28dbbec8e1cc097e5991e1fe19ef497e