Back to Search Start Over

Identification and immunotherapeutic targeting of antigens induced by chemotherapy

Authors :
Paul Polakis
Sharon Fong
Sarajane Ross
Hartmut Koeppen
Bonnee Rubinfeld
Victoria Smith
Archana Upadhyay
Suzanna Clark
Source :
Nature Biotechnology. 24:205-209
Publication Year :
2006
Publisher :
Springer Science and Business Media LLC, 2006.

Abstract

Cancer cells differ from normal cells in their response to chemotherapy. We exploited this dissimilarity by identifying and targeting tumor-specific, cell-surface proteins whose expression is induced by the chemotherapeutic irinotecan (CPT-11; Camptosar). A cytotoxin-armed antibody reactive with one of these drug-induced surface proteins, the LY6D/E48 antigen, originally identified as the target of a monoclonal antibody reactive with squamous cell carcinomas, caused complete regression of colorectal tumor xenografts in mice treated with CPT-11, whereas either agent alone was less effective. These results suggest that a positive therapeutic index may be generated for other drug combinations by immunotherapeutic targeting of chemotherapy-induced antigens.

Details

ISSN :
15461696 and 10870156
Volume :
24
Database :
OpenAIRE
Journal :
Nature Biotechnology
Accession number :
edsair.doi.dedup.....28efb2faf6dbdd002d9e06b8f5421d08
Full Text :
https://doi.org/10.1038/nbt1185