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Identification and immunotherapeutic targeting of antigens induced by chemotherapy
- Source :
- Nature Biotechnology. 24:205-209
- Publication Year :
- 2006
- Publisher :
- Springer Science and Business Media LLC, 2006.
-
Abstract
- Cancer cells differ from normal cells in their response to chemotherapy. We exploited this dissimilarity by identifying and targeting tumor-specific, cell-surface proteins whose expression is induced by the chemotherapeutic irinotecan (CPT-11; Camptosar). A cytotoxin-armed antibody reactive with one of these drug-induced surface proteins, the LY6D/E48 antigen, originally identified as the target of a monoclonal antibody reactive with squamous cell carcinomas, caused complete regression of colorectal tumor xenografts in mice treated with CPT-11, whereas either agent alone was less effective. These results suggest that a positive therapeutic index may be generated for other drug combinations by immunotherapeutic targeting of chemotherapy-induced antigens.
- Subjects :
- medicine.drug_class
medicine.medical_treatment
Molecular Sequence Data
Biomedical Engineering
Mice, Nude
Antineoplastic Agents
Bioengineering
Irinotecan
Monoclonal antibody
Applied Microbiology and Biotechnology
Mice
Drug Delivery Systems
Therapeutic index
Antigen
Antigens, Neoplasm
Cell Line, Tumor
medicine
Animals
Humans
Base Sequence
biology
Antibodies, Monoclonal
Membrane Proteins
Immunotherapy
Treatment Outcome
Epidermoid carcinoma
Immunology
Cancer cell
Carcinoma, Squamous Cell
biology.protein
Molecular Medicine
Camptothecin
Female
Antibody
Biotechnology
medicine.drug
Subjects
Details
- ISSN :
- 15461696 and 10870156
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Nature Biotechnology
- Accession number :
- edsair.doi.dedup.....28efb2faf6dbdd002d9e06b8f5421d08
- Full Text :
- https://doi.org/10.1038/nbt1185