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Leukocytosis, prognosis biomarker in locally advanced head and neck cancer patients after chemoradiotherapy
- Source :
- Clinical and Translational Radiation Oncology, Vol 12, Iss, Pp 8-15 (2018), Clinical and Translational Radiation Oncology
- Publication Year :
- 2018
- Publisher :
- Elsevier, 2018.
-
Abstract
- Highlights • In locally advanced HNSCC, baseline leukocytosis predicts OS and PFS. • Respectively 24% and 20% patients displayed baseline leukocytosis or neutrophilia. • This independent biomarker could help identifying patients with high risk of tumor relapse.<br />Objective To study the prognostic value of leukocyte increase in a retrospective cohort of locally advanced head and neck squamous cell carcinoma (HNSCC) patients receiving definitive concurrent cisplatin and radiation. Materials and methods Clinical records of consecutive previously untreated locally advanced HNSCC patients treated in our Institution between March 2006 and October 2012 by concurrent cisplatin (100 mg/m2, every 3 weeks) and radiation (70 Gy in 7 weeks) were collected. The prognostic value of pretreatment leukocyte increase was examined, with focus on patterns of relapse and survival. Leukocytosis and neutrophilia were defined as a leukocyte count or a neutrophils count exceeding 10 and 7.5 G/L, respectively. Results We identified 193 patients, all treated with concurrent cisplatin-based chemoradiotherapy. Respectively 24% and 20% patients displayed baseline leukocytosis or neutrophilia. Mean leukocyte count were significantly more elevated in current smokers, patients with performance status (PS) >0, T4 and less in HPV + tumor. The 5-year actuarial overall survival (OS) and progression-free survival (PFS) were 56% and 51% respectively. In univariate analysis, both leukocytosis and neutrophilia were strongly associated with worse OS and PFS (p
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Leukocytosis
R895-920
Neutrophilia
Gastroenterology
Article
03 medical and health sciences
Medical physics. Medical radiology. Nuclear medicine
0302 clinical medicine
Internal medicine
Squamous cell carcinoma
medicine
Radiology, Nuclear Medicine and imaging
Head and neck cancer
RC254-282
Univariate analysis
Prognostic factor
Performance status
business.industry
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Head and neck squamous-cell carcinoma
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Biomarker (medicine)
Concurrent chemoradiation
medicine.symptom
business
Chemoradiotherapy
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 24056308
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Clinical and Translational Radiation Oncology
- Accession number :
- edsair.doi.dedup.....28fa4c4e7c141e0ca635c290fdf4c870