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Leukocytosis, prognosis biomarker in locally advanced head and neck cancer patients after chemoradiotherapy

Authors :
Philippe Gorphe
Alexandre Escande
Cyrus Chargari
Stéphane Temam
Yungan Tao
Antonin Levy
Antoine Schernberg
Dan Ou
François Janot
Sarah Atallah
Pierre Blanchard
Alexandre Caula
Ingrid Breuskin
Eric Deutsch
Source :
Clinical and Translational Radiation Oncology, Vol 12, Iss, Pp 8-15 (2018), Clinical and Translational Radiation Oncology
Publication Year :
2018
Publisher :
Elsevier, 2018.

Abstract

Highlights • In locally advanced HNSCC, baseline leukocytosis predicts OS and PFS. • Respectively 24% and 20% patients displayed baseline leukocytosis or neutrophilia. • This independent biomarker could help identifying patients with high risk of tumor relapse.<br />Objective To study the prognostic value of leukocyte increase in a retrospective cohort of locally advanced head and neck squamous cell carcinoma (HNSCC) patients receiving definitive concurrent cisplatin and radiation. Materials and methods Clinical records of consecutive previously untreated locally advanced HNSCC patients treated in our Institution between March 2006 and October 2012 by concurrent cisplatin (100 mg/m2, every 3 weeks) and radiation (70 Gy in 7 weeks) were collected. The prognostic value of pretreatment leukocyte increase was examined, with focus on patterns of relapse and survival. Leukocytosis and neutrophilia were defined as a leukocyte count or a neutrophils count exceeding 10 and 7.5 G/L, respectively. Results We identified 193 patients, all treated with concurrent cisplatin-based chemoradiotherapy. Respectively 24% and 20% patients displayed baseline leukocytosis or neutrophilia. Mean leukocyte count were significantly more elevated in current smokers, patients with performance status (PS) >0, T4 and less in HPV + tumor. The 5-year actuarial overall survival (OS) and progression-free survival (PFS) were 56% and 51% respectively. In univariate analysis, both leukocytosis and neutrophilia were strongly associated with worse OS and PFS (p

Details

Language :
English
ISSN :
24056308
Volume :
12
Database :
OpenAIRE
Journal :
Clinical and Translational Radiation Oncology
Accession number :
edsair.doi.dedup.....28fa4c4e7c141e0ca635c290fdf4c870