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Synthesis, Spectral Characterization, SEM, Antimicrobial, Antioxidative Activity Evaluation, DNA Binding and DNA Cleavage Investigation of Transition Metal(II) Complexes Derived from a tetradentate Schiff base bearing thiophene moiety
- Source :
- Journal of Fluorescence. 27:1051-1066
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- A novel series of Co(II), Ni(II), Cu(II) and Zn(II) mononuclear complexes have been synthesized involving a potentially tetradentate Schiff base ligand, which was obtained by condensation of 2-aminophenol with 2,5-thiophene-dicarboxaldehyde. The complexes were synthesized via reflux reaction of methanolic solution of the appropriate Schiff base ligand with one equivalent of corresponding metal acetate salt. Based on different techniques including micro analysis, FT-IR, NMR, UV-Vis, ESR, ESI-mass and conductivity measurements, four-coordinated geometry was assigned for all complexes. Spectroscopic data have shown that, the reported Schiff base coordinated to metal ions as a dibasic tetradentate ligand through the phenolic oxygen and the azomethine nitrogen. The antimicrobial activities of the parent ligand and its complexes were investigated by using the agar disk diffusion method. Antioxidation properties of the novel complexes were investigated and it was found that all the complexes have good radical scavenging properties. The binding of complexes to calf thymus DNA (CT-DNA) was investigated by absorption, emission and viscosity measurements. Binding studies have shown that all the complexes interacted with CT-DNA via intercalation mode and the binding affinity varies with relative order as Cu(II) complex > Co(II) complex > Zn(II) complex > Ni(II) complex. Furthermore, DNA cleavage properties of the metal complexes were also investigated. The results suggested the possible utilization of novel complexes for pharmaceutical applications.
- Subjects :
- Magnetic Resonance Spectroscopy
Sociology and Political Science
Metal ions in aqueous solution
Clinical Biochemistry
Inorganic chemistry
Intercalation (chemistry)
Microbial Sensitivity Tests
Thiophenes
010402 general chemistry
01 natural sciences
Biochemistry
Antioxidants
Metal
chemistry.chemical_compound
Coordination Complexes
Nickel
Spectroscopy, Fourier Transform Infrared
Polymer chemistry
Thiophene
Moiety
DNA Cleavage
Schiff Bases
Spectroscopy
Schiff base
Dibasic acid
010405 organic chemistry
Electron Spin Resonance Spectroscopy
Cobalt
DNA
Ligand (biochemistry)
Anti-Bacterial Agents
0104 chemical sciences
Zinc
Clinical Psychology
chemistry
visual_art
Microscopy, Electron, Scanning
visual_art.visual_art_medium
Law
Copper
Social Sciences (miscellaneous)
Subjects
Details
- ISSN :
- 15734994 and 10530509
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Journal of Fluorescence
- Accession number :
- edsair.doi.dedup.....2912ccc2da83d5574b9db8a6bf79e868