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Integrated Genomic Characterization of Papillary Thyroid Carcinoma
- Source :
- Agrawal, N, Akbani, R, Aksoy, B A, Ally, A, Arachchi, H, Asa, SL, Auman, J T, Balasundaram, M, Balu, S, Baylin, SB, Behera, M, Bernard, B, Beroukhim, R, Bishop, JA, Black, AD, Bodenheimer, T, Boice, L, Bootwalla, MS, Bowen, J, Bowlby, R, Bristow, CA, Brookens, R, Brooks, D, Bryant, R, Buda, E, Butterfield, YS N, Carling, T, Carlsen, R, Carter, SL, Carty, SE, Chan, TA, Chen, AY, Cherniack, AD, Cheung, D, Chin, L, Cho, J, Chu, A, Chuah, E, Cibulskis, K, Ciriello, G, Clarke, A, Clayman, GL, Cope, L, Copland, JA, Covington, K, Danilova, L, Davidsen, T, Demchok, JA, DiCara, D, Dhalla, N, Dhir, R, Dookran, SS, Dresdner, G, Eldridge, J, Eley, G, El-Naggar, AK, Eng, S, Fagin, JA, Fennell, T, Ferris, RL, Fisher, S, Frazer, S, Frick, J, Gabriel, SB, Ganly, I, Gao, J, Garraway, LA, Gastier-Foster, JM, Getz, G, Gehlenborg, N, Ghossein, R, Gibbs, RA, Giordano, TJ, Gomez-Hernandez, K, Grimsby, J, Gross, B, Guin, R, Hadjipanayis, A, Harper, HA, Hayes, D N, Heiman, DI, Herman, JG, Hoadley, KA, Hofree, M, Holt, RA, Hoyle, AP, Huang, FW, Huang, M, Hutter, CM, Ideker, T, Iype, L, Jacobsen, A, Jefferys, SR, Jones, CD, Jones, SJ M, Kasaian, K, Kebebew, E, Khuri, FR, Kim, J, Kramer, R, Kreisberg, R, Kucherlapati, R, Kwiatkowski, DJ, Ladanyi, M, Lai, PH, Laird, PW, Lander, E, Lawrence, MS, Lee, D, Lee, E, Lee, S, Lee, W, Leraas, KM, Lichtenberg, TM, Lichtenstein, L, Lin, P, Ling, S, Liu, J, Liu, W, Liu, Y, LiVolsi, VA, Lu, Y, Ma, Y, Mahadeshwar, HS, Marra, MA, Mayo, M, McFadden, DG, Meng, S, Meyerson, M, Mieczkowski, PA, Miller, M, Mills, G, Moore, RA, Mose, LE, Mungall, AJ, Murray, BA, Nikiforov, YE, Noble, MS, Ojesina, AI, Owonikoko, TK, Ozenberger, BA, Pantazi, A, Parfenov, M, Park, PJ, Parker, JS, Paull, EO, Pedamallu, CS, Perou, CM, Prins, JF, Protopopov, A, Ramalingam, SS, Ramirez, NC, Ramirez, R, Raphael, BJ, Rathmell, W K, Ren, X, Reynolds, SM, Rheinbay, E, Ringel, MD, Rivera, M, Roach, J, Robertson, A G, Rosenberg, MW, Rosenthal, M, Sadeghi, S, Saksena, G, Sander, C, Santoso, N, Schein, JE, Schultz, N, Schumacher, SE, Seethala, RR, Seidman, J, Senbabaoglu, Y, Seth, S, Sharpe, S, Shaw, KR M, Shen, JP, Shen, R, Sherman, S, Sheth, M, Shi, Y, Shmulevich, I, Sica, GL, Simons, JV, Sinha, R, Sipahimalani, P, Smallridge, RC, Sofia, HJ, Soloway, MG, Song, X, Sougnez, C, Stewart, C, Stojanov, P, Stuart, JM, Sumer, S O, Sun, Y, Tabak, B, Tam, A, Tan, D, Tang, J, Tarnuzzer, R, Taylor, BS, Thiessen, N, Thorne, L, Thorsson, V, Tuttle, R M, Umbricht, CB, Van Den Berg, DJ, Vandin, F, Veluvolu, U, Verhaak, RG W, Vinco, M, Voet, D, Walter, V, Wang, Z, Waring, S, Weinberger, PM, Weinhold, N, Weinstein, JN, Weisenberger, DJ, Wheeler, D, Wilkerson, MD, Wilson, J, Williams, M, Winer, DA, Wise, L, Wu, J, Xi, L, Xu, AW, Yang, L, Yang, L, Zack, TI, Zeiger, MA, Zeng, D, Zenklusen, JC, Zhao, N, Zhang, H, Zhang, J, Zhang, JJ, Zhang, W, Zmuda, E & Zou, L 2014, ' Integrated Genomic Characterization of Papillary Thyroid Carcinoma : Cell ', Cell, vol. 159, no. 3, pp. 676-690 . https://doi.org/10.1016/j.cell.2014.09.050
- Publisher :
- The Authors. Published by Elsevier Inc.
-
Abstract
- Summary Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic alterations (relative to other carcinomas) and extended the set of known PTC driver alterations to include EIF1AX , PPM1D , and CHEK2 and diverse gene fusions. These discoveries reduced the fraction of PTC cases with unknown oncogenic driver from 25% to 3.5%. Combined analyses of genomic variants, gene expression, and methylation demonstrated that different driver groups lead to different pathologies with distinct signaling and differentiation characteristics. Similarly, we identified distinct molecular subgroups of BRAF -mutant tumors, and multidimensional analyses highlighted a potential involvement of oncomiRs in less-differentiated subgroups. Our results propose a reclassification of thyroid cancers into molecular subtypes that better reflect their underlying signaling and differentiation properties, which has the potential to improve their pathological classification and better inform the management of the disease.
- Subjects :
- Genetics and Molecular Biology (all)
DNA Copy Number Variations
endocrine system diseases
Carcinoma
Gene Fusion
Humans
Thyroid Gland
Thyroid Neoplasms
Mutation
Biochemistry, Genetics and Molecular Biology (all)
Medicine (all)
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features
EIF1AX
Biology
Bioinformatics
Biochemistry
Article
General Biochemistry, Genetics and Molecular Biology
Thyroid carcinoma
Poorly Differentiated Thyroid Carcinoma
medicine
CHEK2
Thyroid cancer
Biochemistry, Genetics and Molecular Biology(all)
Thyroid
medicine.disease
Carcinoma, Papillary
Carcinoma/genetics
3. Good health
medicine.anatomical_structure
Thyroid Cancer, Papillary
Thyroid Neoplasms/genetics
Thyroid Gland/cytology
Subjects
Details
- Language :
- English
- ISSN :
- 00928674
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Cell
- Accession number :
- edsair.doi.dedup.....2927c3e3369fab17a6701d202d8c3f84
- Full Text :
- https://doi.org/10.1016/j.cell.2014.09.050