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Genetic study of ICAM1 in clinical malaria in Senegal
- Source :
- Tissue antigens. 65(5)
- Publication Year :
- 2005
-
Abstract
- Many genes have been implicated in the risk of severe malaria, generally based on candidate gene studies in case/control populations. Among these genes, there has been conflicting reports for the implication of a variant of the intercellular adhesion molecule 1 (ICAM1), ICAM1 K i l i f i , in the risk of severe malaria, while in vitro studies provided independent support for a functional role of this variant. In order to explore the possible implication of ICAM1 in the susceptibility/resistance to malaria and to try to understand its clinical relevance in the disease process, we have conducted linkage and association studies of ICAM1 in two Senegalese villages located in regions of endemic malaria. We explored the full genetic variability of ICAM1, and tested it on several clinical malarial traits which are under genetic control, focusing principally on variables related to the parasite density and the number of malarial attacks. Our study provides no evidence for a role of ICAM1 variability on the malarial phenotypes studied.
- Subjects :
- Candidate gene
Genotype
Immunology
Biology
Biochemistry
Polymorphism, Single Nucleotide
Cohort Studies
Gene Frequency
Genetics
medicine
Immunology and Allergy
Animals
Humans
Clinical significance
Genetic Predisposition to Disease
Genetic variability
Malaria, Falciparum
Gene
Parasite density
Genetic association
General Medicine
medicine.disease
Intercellular Adhesion Molecule-1
Phenotype
Senegal
Haplotypes
Lod Score
Chromosomes, Human, Pair 19
Malaria
Microsatellite Repeats
Subjects
Details
- ISSN :
- 00012815
- Volume :
- 65
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Tissue antigens
- Accession number :
- edsair.doi.dedup.....29375e745669ba67bbadc4820d0923c2