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Seminal Plasma Transcriptome and Proteome: Towards a Molecular Approach in the Diagnosis of Idiopathic Male Infertility
- Source :
- International Journal of Molecular Sciences, Vol 21, Iss 7308, p 7308 (2020), International Journal of Molecular Sciences
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- As the “-omic” technology has largely developed, its application in the field of medical science seems a highly promising tool to clarify the etiology, at least in part, of the so-called idiopathic male infertility. The seminal plasma (SP) is made-up of secretions coming from the male accessory glands, namely epididymis, seminal vesicles, and prostate. It is not only a medium for sperm transport since it is able to modulate the female reproductive environment and immunity, to allow the acquisition of sperm competence, to influence the sperm RNA content, and even embryo development. The aim of this systematic review was to provide an updated and comprehensive description of the main transcripts and proteins reported by transcriptome and proteome studies performed in the human SP of patients with idiopathic infertility, in the attempt of identifying possible candidate molecular targets. We recurrently found that micro RNA (miR)-34, miR-122, and miR-509 are down-regulated in patients with non-obstructive azoospermia (NOA) and oligozoospermia compared with fertile controls. These molecules may represent interesting targets whose predictive role in testicular sperm extraction (TESE) or assisted reproductive techniques (ART) outcome deserves further investigation. Furthermore, according to the available proteomic studies, ECM1, TEX101, lectingalactoside-binding andsoluble 3 binding protein (LGALS3BP) have been reported as accurate predictors of TESE outcome. Interestingly, ECM1 is differently expressed in patients with different ART outcomes. Further prospective, ample-sized studies are needed to validate these molecular targets that will help in the counseling of patients with NOA or undergoing ART.
- Subjects :
- Male
Proteomics
0301 basic medicine
Proteome
Review
Biology
Bioinformatics
Catalysis
Male infertility
lcsh:Chemistry
Inorganic Chemistry
Transcriptome
03 medical and health sciences
0302 clinical medicine
Semen
Prostate
medicine
Humans
male idiopathic infertility
Physical and Theoretical Chemistry
lcsh:QH301-705.5
Molecular Biology
Infertility, Male
Spectroscopy
Azoospermia
030219 obstetrics & reproductive medicine
Organic Chemistry
General Medicine
seminal fluid proteome
seminal fluid transcriptome, seminal fluid proteome, male idiopathic infertility, oligozoospermia
Epididymis
medicine.disease
Spermatozoa
Sperm
Testicular sperm extraction
oligozoospermia
Computer Science Applications
030104 developmental biology
medicine.anatomical_structure
lcsh:Biology (General)
lcsh:QD1-999
seminal fluid transcriptome
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....293df18135eae40fcd3fd35daf23584d
- Full Text :
- https://doi.org/10.3390/ijms21197308