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Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity
- Source :
- Data in Brief, Vol 23, Iss, Pp-(2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- This data article is associated with the manuscript "GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: elucidating potential anti-atherothrombotic targets in obesity" [1]. The study refers to a combination of different approaches in order to identify platelet-derived biomarkers in obesity. A total of 34 obese patients and their lean-matched controls were included in the study. We carried out a proteomic and functional (aggregation assays) analysis to find alterations in platelet-derived signalling pathways. After that, biochemical and mechanistic (flow cytometry assays) approaches were done in order to confirm a hyperactivation of the GPVI-related signalling pathway.
- Subjects :
- 2 Aetiology
32 Biomedical and Clinical Sciences
Hematology
3101 Biochemistry and Cell Biology
Cardiovascular
lcsh:Computer applications to medicine. Medical informatics
Stroke
Clinical Research
2.1 Biological and endogenous factors
lcsh:R858-859.7
Obesity
lcsh:Science (General)
31 Biological Sciences
Nutrition
Cancer
lcsh:Q1-390
Subjects
Details
- Language :
- English
- ISSN :
- 23523409
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Data in Brief
- Accession number :
- edsair.doi.dedup.....293ed3a28e2bf39a408c06deaac486e9