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Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition

Authors :
Jenny C. Chang
Jianting Sheng
Jiyong Liu
Hong Zhao
Zhen Zhao
Kemi Cui
Jiang Wang
Jing Zhong
Xiaoping Zhu
Stephen T. C. Wong
Source :
Oncotarget
Publication Year :
2015
Publisher :
Impact Journals, LLC, 2015.

Abstract

Interactions among tumor cells, stromal cells, and extracellular matrix compositions are mediated through cytokines during tumor progression. Our analysis of 132 known cytokines and growth factors in published clinical breast cohorts and our 84 patient-derived xenograft models revealed that the elevated connective tissue growth factor (CTGF) in tumor epithelial cells significantly correlated with poor clinical prognosis and outcomes. CTGF was able to induce tumor cell epithelial-mesenchymal transition (EMT), and promote stroma deposition of collagen I fibers to stimulate tumor growth and metastasis. This process was mediated through CTGF-tumor necrosis factor receptor I (TNFR1)-IκB autocrine signaling. Drug treatments targeting CTGF, TNFR1, and IκB signaling each prohibited the EMT and tumor progression.

Details

ISSN :
19492553
Volume :
6
Database :
OpenAIRE
Journal :
Oncotarget
Accession number :
edsair.doi.dedup.....2941649ca932bfac69bb4aa73da06361