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Abnormal circadian locomotor rhythms and Per gene expression in six-month-old triple transgenic mice model of Alzheimer’s disease
- Source :
- Neuroscience Letters. 676:13-18
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Circadian rhythm disturbance (CRD) is one of the iconic manifestations in Alzheimer’s disease (AD), a disease tightly associated with age, but the characteristics and gender difference of CRD occurred in AD have not been well demonstrated. Using 6-month-old triple transgenic AD mouse model (3xTg-AD) without obvious brain pathological changes, we demonstrated the gender difference of CRD at this age. We further showed abnormal Per gene expression in the central clock suprachiasmatic nucleus (SCN) of the 3xTg-AD mice. Specifically, compared with the wide type (WT) mice, the 3xTg-AD mice showed disrupted circadian locomotor rhythms both at LD (light-dark 12 h:12 h) and DD (constant dark) conditions, such as increased activities in the resting phase, decreased and scattered activities in the active phase, decreased overall activity intensities, amplitude, robustness, and increased intradaily variability. We further observed that 3xTg-AD female mice showed obviously less CRD compared with the 3xTg-AD male mice, and female mice of both WT and 3xTg-AD were more active in locomotor activity. Accordingly, 3xTg-AD mice showed a phase delay in the expression of Per1 and Per2 mRNA in the SCN, with the levels of Per1 and Per2 mRNA were significantly lower than that of WT mice at specific time points. We conclude that 3xTg-AD mice exhibit behavioral CRD at the age of six months with male gender preference, and these phenomena are at least partly associated with the alteration of Per1 and Per2 transcription patterns in the SCN.
- Subjects :
- Male
0301 basic medicine
Genetically modified mouse
endocrine system
medicine.medical_specialty
Genotype
Transgene
Gene Expression
Mice, Transgenic
Motor Activity
Biology
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
Internal medicine
medicine
Animals
Circadian rhythm
Pathological
Sex Characteristics
Messenger RNA
Suprachiasmatic nucleus
General Neuroscience
Period Circadian Proteins
Circadian Rhythm
Mice, Inbred C57BL
PER2
Disease Models, Animal
030104 developmental biology
Endocrinology
Female
Suprachiasmatic Nucleus
Locomotion
030217 neurology & neurosurgery
PER1
Subjects
Details
- ISSN :
- 03043940
- Volume :
- 676
- Database :
- OpenAIRE
- Journal :
- Neuroscience Letters
- Accession number :
- edsair.doi.dedup.....2943cbfba95136e197ad585b3c262df9