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Impact of systemic antimicrobial therapy on mucosal staphylococci in a population of dogs in Northwest England
- Source :
- Schmidt, V, Pinchbeck, G, Nuttall, T, Shaw, S, McIntyre, K, McEwan, N, Dawson, S & Williams, N 2018, ' Impact of systemic antimicrobial therapy on mucosal staphylococci in a population of dogs in Northwest England ', Veterinary Dermatology, vol. 29, no. 3, pp. 192-e70 . https://doi.org/10.1111/vde.12538, Veterinary Dermatology: an international journal, VETERINARY DERMATOLOGY
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Background Antimicrobial-resistant bacteria are increasingly isolated from veterinary patients. Objectives To determine risk factors for antimicrobial resistance (AMR) among canine mucosal staphylococci following routine antimicrobial treatment with cefalexin (CFX), clavulanate-amoxicillin (AC), cefovecin (CVN), clindamycin (CD) or a fluoroquinolone (FQ). Animals Mucosal swab samples (n = 463) were collected from 127 dogs pre-treatment, immediately, and at one- and three-months post-treatment. Methods Staphylococci were identified phenotypically and biochemically as coagulase negative (CoNS) or coagulase positive (CoPS); CoPS were speciated by nuc gene PCR. Antimicrobial susceptibility was determined using disc diffusion and mecA gene carriage by PCR. Multilevel, multivariable models examined associations between risk factors and presence/absence of CoPS, meticillin resistance (MR), multidrug-resistance (MDR) and fluoroquinolone resistance (FQR). Results The percentage of samples with CoNS increased and with CoPS (including S. pseudintermedius) decreased immediately post-treatment with CFX, CVN and CD (P ≤ 0.001) and one month post-treatment with CD (P = 0.003). By three months post-treatment, there was no significant difference compared to pre-treatment samples. Immediately post-treatment with FQs there was significantly increased risk of isolating MRS (P = 0.002), MDR (P = 0.002) or FQR (P = 0.013) staphylococci and of MDR following CFX treatment (P = 0.019). The percentage of samples with AMR staphylococci declined from immediately to three months post-treatment and there was no significant difference between resistance prevalence at one or three months post-treatment for most AMR traits and treatment groups. Exceptions include increased MDR following FQ (P = 0.048) or CFX (P = 0.021), at one and three months post-treatment, respectively. Conclusions and clinical importance Systemic antimicrobials impact on mucosal staphylococci. Immediately after therapy, the mucosa may be a reservoir for AMR staphylococci that are a source of mobile genetic elements carrying AMR genes.
- Subjects :
- 0301 basic medicine
Meticillin
Staphylococcus
030106 microbiology
Population
Cefovecin
Microbial Sensitivity Tests
Drug resistance
Microbiology
03 medical and health sciences
chemistry.chemical_compound
Dogs
Antibiotic resistance
Drug Resistance, Multiple, Bacterial
Animals
Medicine
Dog Diseases
education
Antiinfective agent
education.field_of_study
Mucous Membrane
General Veterinary
business.industry
SCCmec
Staphylococcal Infections
Anti-Bacterial Agents
030104 developmental biology
England
chemistry
Methicillin Resistance
Coagulase
business
medicine.drug
Subjects
Details
- ISSN :
- 09594493
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Veterinary Dermatology
- Accession number :
- edsair.doi.dedup.....2947476f17d6ea05ed68a2fbfcb07251