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A White Paper on Collagen Hydrolyzates and Ultrahydrolyzates: Potential Supplements to Support Joint Health in Osteoarthritis?
- Source :
- Current Rheumatology Reports, 23(11):78. Springer, Cham, Current Rheumatology Reports
- Publication Year :
- 2021
-
Abstract
- Purpose of Review Osteoarthritis (OA) is the most common forms of arthritis in the general population, accounting for more pain and functional disability than any other musculoskeletal disease. There are currently no approved disease modifying drugs for OA. In the absence of effective pharmacotherapy, many patients with OA turn to nutritional supplements and nutraceuticals, including collagen derivatives. Collagen hydrolyzates and ultrahydrolyzates are terms used to describe collagens that have been broken down into small peptides and amino acids in the presence of collagenases and high pressure. Recent Findings This article reviews the relevant literature and serves as a White Paper on collagen hydrolyzates and ultrahydrolyzates as emerging supplements often advertised to support joint health in OA. Collagen hydrolyzates have demonstrated some evidence of efficacy in a handful of small scale clinical trials, but their ability to treat and reverse advanced joint disease remains highly speculative, as is the case for other nutritional supplements. Summary The aim of this White Paper is to stimulate research and development of collagen-based supplements for patients with OA and other musculoskeletal diseases at academic and industrial levels. This White Paper does not make any treatment recommendations for OA patients in the clinical context, but simply aims to highlight opportunities for scientific innovation and interdisciplinary collaboration, which are crucial for the development of novel products and nutritional interventions based on the best available and published evidence.
- Subjects :
- collagen
medicine.medical_specialty
Population
Pain
Arthritis
Context (language use)
Osteoarthritis
Disease
METABOLISM
dietary supplements
Denatured collagen
Nutraceutical
Pharmacotherapy
Rheumatology
FOOD
Complementary and Alternative Medicine (S Kolasinski, Section Editor)
Osteoarthritis/drug therapy
Humans
Medicine
HYDROLYSATE
Intensive care medicine
education
Nutritional supplement
education.field_of_study
business.industry
Collagen hydrolyzate
GUT MICROBIOTA
IN-VITRO DIGESTION
medicine.disease
UC-II
Clinical trial
Collagen ultra-hydrolyzate
ORAL TOLERANCE
II COLLAGEN
IMMUNE-SYSTEM
Joint health
Joint Diseases
business
DIETARY-SUPPLEMENTS
Subjects
Details
- Language :
- English
- ISSN :
- 15233774
- Volume :
- 23
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Current Rheumatology Reports
- Accession number :
- edsair.doi.dedup.....295d22a9d9cd697f039175b18eafe3ec