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Occurrence and severity of cocaine-induced hallucinations: Two distinct phenotypes with shared clinical factors but specific genetic risk factors

Authors :
El-Hadi Zerdazi
Emmanuel Curis
Emily Karsinti
Romain Icick
Maeva Fortias
Philippe Batel
Olivier Cottencin
Cyrille Orizet
Aurélia Gay
Philippe Coeuru
Alice Deschenau
Philippe Lack
Delphine Moisan
Anne-Laure Pelissier-Alicot
Arnaud Plat
Jean-Baptiste Trabut
Isabelle Kousignian
Luana Boumendil
Eric Vicaut
Nathalie Prince
Jean-Louis Laplanche
Frank Bellivier
Jean-Pierre Lépine
Cynthia Marie-Claire
Georges Brousse
Florence Vorspan
Vanessa Bloch
Source :
Drug and alcohol dependence. 232
Publication Year :
2021

Abstract

Cocaine-induced transient hallucinations (CIH) are a frequent complication following cocaine intake that is associated with addiction severity.Two hundred and forty-two non-psychotic and Caucasian lifetime cocaine users were included in a French multicentric study. Clinical variables and dopamine pathway genotype data were extracted and tested with CIH scores using a zero-inflated binomial model, which allows for the exploration of factors associated with occurrence and severity separately.Cocaine dependence (pOur study shows that CIH occurrence and severity are two distinct phenotypes, with shared clinical risk factors; however, they likely do not share the same genetic background.

Details

ISSN :
18790046
Volume :
232
Database :
OpenAIRE
Journal :
Drug and alcohol dependence
Accession number :
edsair.doi.dedup.....2971a6868dce5a9fd5b5a6fde0b756db