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Occurrence and severity of cocaine-induced hallucinations: Two distinct phenotypes with shared clinical factors but specific genetic risk factors
- Source :
- Drug and alcohol dependence. 232
- Publication Year :
- 2021
-
Abstract
- Cocaine-induced transient hallucinations (CIH) are a frequent complication following cocaine intake that is associated with addiction severity.Two hundred and forty-two non-psychotic and Caucasian lifetime cocaine users were included in a French multicentric study. Clinical variables and dopamine pathway genotype data were extracted and tested with CIH scores using a zero-inflated binomial model, which allows for the exploration of factors associated with occurrence and severity separately.Cocaine dependence (pOur study shows that CIH occurrence and severity are two distinct phenotypes, with shared clinical risk factors; however, they likely do not share the same genetic background.
Details
- ISSN :
- 18790046
- Volume :
- 232
- Database :
- OpenAIRE
- Journal :
- Drug and alcohol dependence
- Accession number :
- edsair.doi.dedup.....2971a6868dce5a9fd5b5a6fde0b756db