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Synthesis, radiosynthesis, and positron emission tomography neuroimaging using 5-[18 F]fluoro-L-amino suberate

Authors :
Eirik Malinen
Santosh R. Alluri
Patrick J. Riss
Kathinka E. Pitman
Source :
Journal of Labelled Compounds and Radiopharmaceuticals. 63:6-14
Publication Year :
2019
Publisher :
Wiley, 2019.

Abstract

System xc- (Sxc -) has emerged as a new biological target for PET studies to detect oxidative and excitotoxic stress. Notably, applications have, thus far, been limited to tumour imaging although Sxc- ) may play a major role in neurodegeneration. The synthesis procedures of tosylate precursor and its translation to Sxc - PET tracer 5[18F]fluoro-L-amino suberate by manual and automated radiosyntheses are described. A brain-PET study has been conducted to evaluate the tracer uptake into brain in healthy mice.

Details

ISSN :
03624803
Volume :
63
Database :
OpenAIRE
Journal :
Journal of Labelled Compounds and Radiopharmaceuticals
Accession number :
edsair.doi.dedup.....29754e54cead8d3e16a949934fc664bd