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Synthesis, radiosynthesis, and positron emission tomography neuroimaging using 5-[18 F]fluoro-L-amino suberate
- Source :
- Journal of Labelled Compounds and Radiopharmaceuticals. 63:6-14
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- System xc- (Sxc -) has emerged as a new biological target for PET studies to detect oxidative and excitotoxic stress. Notably, applications have, thus far, been limited to tumour imaging although Sxc- ) may play a major role in neurodegeneration. The synthesis procedures of tosylate precursor and its translation to Sxc - PET tracer 5[18F]fluoro-L-amino suberate by manual and automated radiosyntheses are described. A brain-PET study has been conducted to evaluate the tracer uptake into brain in healthy mice.
- Subjects :
- medicine.diagnostic_test
010405 organic chemistry
Chemistry
Organic Chemistry
Radiosynthesis
01 natural sciences
Biochemistry
030218 nuclear medicine & medical imaging
0104 chemical sciences
Analytical Chemistry
03 medical and health sciences
0302 clinical medicine
Nuclear magnetic resonance
Neuroimaging
Biological target
Positron emission tomography
Drug Discovery
Tracer uptake
medicine
Radiology, Nuclear Medicine and imaging
Pet tracer
Tumour imaging
Spectroscopy
Subjects
Details
- ISSN :
- 03624803
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- Journal of Labelled Compounds and Radiopharmaceuticals
- Accession number :
- edsair.doi.dedup.....29754e54cead8d3e16a949934fc664bd