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The Diagnostic Value of Cardiac Deceleration Capacity in Vasovagal Syncope
- Source :
- Circulation: Arrhythmia and Electrophysiology. 13
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- Background: Increased parasympathetic activity is thought to play important roles in syncope events of patients with vasovagal syncope (VVS). However, direct measurements of the vagal control are difficult. The novel deceleration capacity (DC) of heart rate measure has been used to characterize the vagal modulation. This study aimed to assess vagal control in patients with VVS and evaluate the diagnostic value of the DC in VVS. Methods: Altogether, 161 consecutive patients with VVS (43±15 years; 62 males) were enrolled. Tilt table test was positive in 101 and negative in 60 patients. Sixty-five healthy subjects were enrolled as controls. DC and heart rate variability in 24-hour ECG, echocardiogram, and biochemical examinations were compared between the syncope and control groups. Results: DC was significantly higher in the syncope group than in the control group (9.6±3.3 versus 6.5±2.0 ms, P P =0.614). In multivariable logistic regression analyses, DC was independently associated with syncope (odds ratio=1.518 [95% CI, 1.301–1.770]; P =0.0001). For the prediction of syncope, the area under curve analysis showed similar values when comparing single DC and combined DC with other risk factors ( P =0.1147). From the receiver operator characteristic curves for syncope discrimination, the optimal cutoff value for the DC was 7.12 ms. Conclusions: DC>7.5 ms may serve as a good tool to monitor cardiac vagal activity and discriminate VVS, particularly in those with negative tilt table test.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
030204 cardiovascular system & hematology
Increased Parasympathetic Activity
03 medical and health sciences
0302 clinical medicine
Heart Rate
Predictive Value of Tests
Risk Factors
Tilt-Table Test
Physiology (medical)
Internal medicine
Heart rate
Area under curve
Syncope, Vasovagal
medicine
Humans
030212 general & internal medicine
Vasovagal syncope
biology
Cardiac deceleration
business.industry
Syncope (genus)
Heart
Vagus Nerve
Middle Aged
medicine.disease
biology.organism_classification
Case-Control Studies
Electrocardiography, Ambulatory
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 19413084 and 19413149
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Circulation: Arrhythmia and Electrophysiology
- Accession number :
- edsair.doi.dedup.....297a770a2495d536d57e2c464a79fc86