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Evaluation of the Molecular Landscape in PD-L1 Positive Metastatic NSCLC: Data from Campania, Italy
- Source :
- International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8541
- Publication Year :
- 2022
- Publisher :
- MDPI AG, 2022.
-
Abstract
- Background: Immune-checkpoint inhibitors (ICIs) have increased and improved the treatment options for patients with non-oncogene-addicted advanced stage non-small cell lung cancer (NSCLC). However, the role of ICIs in oncogene-addicted advanced stage NSCLC patients is still debated. In this study, in an attempt to fill in the informational gap on the effect of ICIs on other driver mutations, we set out to provide a molecular landscape of clinically relevant oncogenic drivers in programmed death-ligand 1 (PD-L1) positive NSCLC patients. Methods: We retrospectively reviewed data on 167 advanced stage NSCLC PD-L1 positive patients (≥1%) who were referred to our clinic for molecular evaluation of five driver oncogenes, namely, EGFR, KRAS, BRAF, ALK and ROS1. Results: Interestingly, n = 93 (55.7%) patients showed at least one genomic alteration within the tested genes. Furthermore, analyzing a subset of patients with PD-L1 tumor proportion score (TPS) ≥ 50% and concomitant gene alterations (n = 8), we found that n = 3 (37.5%) of these patients feature clinical benefit with ICIs administration, despite the presence of a concomitant KRAS gene alteration. Conclusions: In this study, we provide a molecular landscape of clinically relevant biomarkers in NSCLC PD-L1 positive patients, along with data evidencing the clinical benefit of ICIs in patient NSCLC PD-L1 positive alterations.
- Subjects :
- molecular oncology
molecular pathology
PD-L1
immune-checkpoint inhibitors
biomarkers
immune-checkpoint inhibitor
Lung Neoplasms
Organic Chemistry
General Medicine
Protein-Tyrosine Kinases
Catalysis
B7-H1 Antigen
Computer Science Applications
Inorganic Chemistry
Proto-Oncogene Proteins p21(ras)
Carcinoma, Non-Small-Cell Lung
Proto-Oncogene Proteins
Mutation
Humans
biomarker
Physical and Theoretical Chemistry
Molecular Biology
Spectroscopy
Retrospective Studies
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8541
- Accession number :
- edsair.doi.dedup.....2995e680305af52d4b2cc9cad16a3770