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Incontinentia Pigmenti Misdiagnosed as Neonatal Herpes Simplex Virus Infection
- Source :
- Case Reports in Pediatrics, Case Reports in Pediatrics, Vol 2018 (2018)
- Publication Year :
- 2018
- Publisher :
- Hindawi Limited, 2018.
-
Abstract
- Incontinentia pigmenti (IP) is an X-linked dominant neurocutaneous syndrome with ophthalmologic, neurologic, cutaneous, and dental manifestations and in most cases antenatally lethal in boys. Occasionally, typical IP may occur in boys due to Klinefelter syndrome or a genomic mosaicism. Skin lesions are observed in 4 stages: blistering, verrucous linear plaques, swirling macular hyperpigmentation, followed by linear hypopigmentation that develop during adolescence and early adulthood. Neonatal herpes simplex virus (HSV) infection can be manifested in 3 forms: localized, disseminated, and central nervous system (CNS) involvement. Timely diagnosis and treatment of neonatal HSV infection is critical. In this case report, we present a 12-day female newborn with a history of maternal genital HSV in second trimester and vesicular lesions on the upper and lower limbs that was appeared at first hours of life. She was admitted in the maternity hospital that was born and was treated by antibiotic and acyclovir for 11 days. Then, she readmitted for her distributed vesicular lesions. The results of blood and CSF for HSV PCR were negative. Eventually the diagnosis for incontinentia pigmenti was made by consultation with a dermatologist, and skin biopsy confirmed the diagnosis.
- Subjects :
- medicine.medical_specialty
medicine.drug_class
Antibiotics
Central nervous system
Case Report
medicine.disease_cause
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
030225 pediatrics
medicine
Hypopigmentation
medicine.diagnostic_test
business.industry
Macular hyperpigmentation
lcsh:RJ1-570
lcsh:Pediatrics
General Medicine
Incontinentia pigmenti
medicine.disease
Dermatology
Herpes simplex virus
medicine.anatomical_structure
Skin biopsy
Klinefelter syndrome
medicine.symptom
business
Subjects
Details
- ISSN :
- 20906811 and 20906803
- Volume :
- 2018
- Database :
- OpenAIRE
- Journal :
- Case Reports in Pediatrics
- Accession number :
- edsair.doi.dedup.....29fedfa793424e5cc8f339f31325e49c