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Dopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans -[ 18 F]Mefway
- Source :
- Applied Radiation and Isotopes. 94:30-34
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- The purpose of the present study is to investigate the relationship between dopaminergic neuron destruction and 5-HT system changes in a hemiparkinsonian rat model. We performed PET imaging studies with trans -[ 18 F]Mefway in a hemiparkinsonian model of unilateral 6-hydroxydopamine (6-OHDA) rats. Region-of-interests (ROIs) were drawn in the hippocampus (HP) and cerebellum (CB). HP uptake, the ratios of specific binding to non-specific binding in the HP, and non-displaceable binding potential (BP ND ) in the HP were compared between 6-OHDA and control rats. As a result, unilateral 6-OHDA-lesioned rats exhibited significant bilateral reduction of HP uptake and trans -[ 18 F]Mefway BP ND compared to the intact control group. Therefore, the results demonstrate that destruction of the dopaminergic system causes the reduction of the serotonergic system.
- Subjects :
- Male
Fluorine Radioisotopes
medicine.medical_specialty
Cerebellum
Metabolic Clearance Rate
Pyridines
Hippocampus
Hippocampal formation
Serotonergic
Sensitivity and Specificity
Piperazines
Rats, Sprague-Dawley
Parkinsonian Disorders
Internal medicine
medicine
Animals
Tissue Distribution
Radionuclide Imaging
5-HT receptor
Radiation
Chemistry
Dopaminergic Neurons
Dopaminergic
Reproducibility of Results
Binding potential
Rats
Endocrinology
medicine.anatomical_structure
nervous system
Anesthesia
Receptor, Serotonin, 5-HT1A
Serotonin
Radiopharmaceuticals
Subjects
Details
- ISSN :
- 09698043
- Volume :
- 94
- Database :
- OpenAIRE
- Journal :
- Applied Radiation and Isotopes
- Accession number :
- edsair.doi.dedup.....2a1399658d0bd38b8274427e1e1ede42