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Hypertension, antihypertensives and mutations in the Von Hippel-Lindau gene in renal cell carcinoma: results from the Netherlands Cohort Study
- Source :
- Journal of Hypertension, 23(11), 1997-2004. LIPPINCOTT WILLIAMS & WILKINS, Journal of Hypertension, 23, 11, pp. 1997-2004, Journal of Hypertension, 23, 1997-2004, Journal of Hypertension, 11, 23, 1997-2004
- Publication Year :
- 2005
-
Abstract
- Contains fulltext : 47661.pdf (Publisher’s version ) (Closed access) OBJECTIVES: Hypertension and/or antihypertensive medication are reported to be risk factors of renal cell carcinoma (RCC). We investigated whether these risk factors are associated with von Hippel-Lindau gene (VHL) mutations in RCC. METHODS: The Netherlands Cohort Study on Diet and Cancer (NLCS) started in 1986 (n = 120 852 men and women) and uses the case-cohort methodology. After 11.3 years of follow-up, 337 RCC cases and 4774 subcohort members were available for analysis. DNA was isolated from paraffin-embedded tumour tissue for VHL analysis. RESULTS: Cohort members who reported hypertension or use of antihypertensive medication had a slightly (non-significant) increased risk of RCC: rate ratios (RR) 1.22 [95% confidence interval (CI), 0.94-1.58] and 1.14 (95% CI, 0.85-1.52), respectively. RRs were adjusted for sex, age, body mass index (BMI) and cigarette smoking. Of the 235 patients for whom tumour tissue specimens were collected, 187 had a clear-cell RCC, of whom 114 had a VHL mutation. History of hypertension was associated with a non-significantly increased risk of clear-cell RCC with VHL mutations: RR = 1.34 (95% CI, 0.87-2.07), and was not associated with the risk of clear-cell RCC without VHL mutations; RR = 0.88 (95% CI, 0.51-1.53). Use of diuretics was associated with clear-cell RCC without VHL mutations; RR = 2.11 (95% CI, 1.16-3.83). CONCLUSIONS: In this study non-significantly increased risks for history of hypertension and use of antihypertensive medication with RCC were observed. The association with hypertension was stronger in RCC patients with VHL mutations, while there was a positive association of diuretics use and risk of RCC without VHL mutations.
- Subjects :
- Oncology
Male
Genetics and epigenetic pathways of disease [NCMLS 6]
Physiology
Statistics as Topic
kidney carcinoma
cigarette smoking
genetic analysis
Aetiology, screening and detection [ONCOL 5]
Gene mutation
cancer risk
genetic risk
urologic and male genital diseases
paraffin
Cohort Studies
Diet and cancer
Renal cell carcinoma
Risk Factors
Determinants in Health and Disease [EBP 1]
gene mutation
Molecular diagnosis, prognosis and monitoring [UMCN 1.2]
Netherlands
Antihypertensive medication
adult
Statistics
article
Middle Aged
cohort analysis
Kidney Neoplasms
female genital diseases and pregnancy complications
female
Treatment Outcome
priority journal
Von Hippel-Lindau Tumor Suppressor Protein
Cohort
Hypertension
antihypertensive agent
Female
Cardiology and Cardiovascular Medicine
Cohort study
VHL mutations
von Hippel Lindau protein
medicine.medical_specialty
hypertension
Food and Chemical Risk Analysis
Molecular epidemiology [NCEBP 1]
Translational research [ONCOL 3]
Interventional oncology [UMCN 1.5]
Internal medicine
Internal Medicine
medicine
Humans
human
Biology
Carcinoma, Renal Cell
neoplasms
Antihypertensive Agents
Aged
Hereditary cancer and cancer-related syndromes [ONCOL 1]
business.industry
diuretic agent
Kidney Carcinoma
Case-control study
The Netherlands
medicine.disease
DNA isolation
major clinical study
body mass
Endocrinology
Case-Control Studies
Mutation
business
Body mass index
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 02636352
- Database :
- OpenAIRE
- Journal :
- Journal of Hypertension, 23(11), 1997-2004. LIPPINCOTT WILLIAMS & WILKINS, Journal of Hypertension, 23, 11, pp. 1997-2004, Journal of Hypertension, 23, 1997-2004, Journal of Hypertension, 11, 23, 1997-2004
- Accession number :
- edsair.doi.dedup.....2a1668f843fa8c963e096b8f21e8ce6e