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Rapid analysis of 65 pharmaceuticals and 7 personal care products in plasma and whole-body tissue samples of fish using acidic extraction, zirconia-coated silica cleanup, and liquid chromatography-tandem mass spectrometry
- Source :
- Journal of Chromatography A. 1631:461586
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- The presence of pharmaceuticals and personal care products (PPCPs) in aquatic systems has raised concern about their potential adverse effects on aquatic organisms. Considering the fact that the physiological/biological effects of PPCPs are triggered when their concentrations in the organism exceeds the respective threshold values, it is important to understand the bioconcentration and toxicokinetics of PPCPs in aquatic organisms. In the present study, we developed a convenient analytical method for the determination of 65 pharmaceuticals and 7 personal care products (log Kow = 0.14–6.04) in plasma and whole-body tissues of fish. The analytical method consists of ultrasound-assisted extraction in methanol/acetonitrile (1:1, v/v,) acidified with acetic acid-ammonium acetate buffer (pH 4), cleanup on a HybridSPE®-Phospholipid cartridge (zirconia-coated silica cartridge), and quantification with liquid chromatography-tandem mass spectrometry (LC–MS/MS). Acceptable accuracy (internal standard-corrected recovery: 70%–120%) and intra- and inter-day precision (coefficient of variation
- Subjects :
- Bioconcentration
Cosmetics
010402 general chemistry
Mass spectrometry
01 natural sciences
Biochemistry
Environmental impact of pharmaceuticals and personal care products
Analytical Chemistry
Cartridge
chemistry.chemical_compound
Tandem Mass Spectrometry
Liquid chromatography–mass spectrometry
Animals
Toxicokinetics
Acetonitrile
Chromatography
010401 analytical chemistry
Organic Chemistry
Extraction (chemistry)
General Medicine
Silicon Dioxide
0104 chemical sciences
Pharmaceutical Preparations
chemistry
Zirconium
Water Pollutants, Chemical
Chromatography, Liquid
Subjects
Details
- ISSN :
- 00219673
- Volume :
- 1631
- Database :
- OpenAIRE
- Journal :
- Journal of Chromatography A
- Accession number :
- edsair.doi.dedup.....2a20be080584b9773e339a31fb85dca8