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KLF5 promotes cervical cancer proliferation, migration and invasion in a manner partly dependent on TNFRSF11a expression
- Source :
- Scientific Reports, Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
- Publication Year :
- 2017
- Publisher :
- Nature Publishing Group UK, 2017.
-
Abstract
- Although the transcription factor Krüppel-like factor 5 (KLF5) plays important roles in both inflammation and cancer, the mechanism by which this factor promotes cervical carcinogenesis remains unclear. In this study, we demonstrated a potential role for tumour necrosis factor receptor superfamily member 11a (TNFRSF11a), the corresponding gene of which is a direct binding target of KLF5, in tumour cell proliferation and invasiveness. Coexpression of KLF5 and TNFRSF11a correlated significantly with tumorigenesis in cervical tissues (P in vivo functional TNFRSF11a-knockdown mouse studies revealed suppression of tumorigenicity and liver metastatic potential. Notably, tumour necrosis factor (TNF)-α induced KLF5 expression by activating the p38 signalling pathway and high KLF5 and TNFRSF11a expression increased the risk of death in patients with cervical squamous cell carcinoma. Our results demonstrate that KLF5 and TNFRSF11a promote cervical cancer cell proliferation, migration and invasiveness.
- Subjects :
- 0301 basic medicine
Kruppel-Like Transcription Factors
lcsh:Medicine
Uterine Cervical Neoplasms
Inflammation
Mice, SCID
Biology
medicine.disease_cause
p38 Mitogen-Activated Protein Kinases
Article
03 medical and health sciences
0302 clinical medicine
Cell Movement
Cell Line, Tumor
medicine
Animals
Humans
Neoplasm Invasiveness
Receptor
lcsh:Science
Promoter Regions, Genetic
Transcription factor
Cell Proliferation
Multidisciplinary
Receptor Activator of Nuclear Factor-kappa B
Cell growth
Tumor Necrosis Factor-alpha
lcsh:R
Cancer
Middle Aged
medicine.disease
Survival Analysis
Hedgehog signaling pathway
Gene Expression Regulation, Neoplastic
030104 developmental biology
030220 oncology & carcinogenesis
Cancer research
Carcinoma, Squamous Cell
Tumor necrosis factor alpha
lcsh:Q
Female
medicine.symptom
Carcinogenesis
Protein Binding
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....2a2c683cfe9aad2a92311fa8ae699f78