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Design of a study to investigate the mechanisms of obstructive sleep apnoea by means of drug-induced sleep endoscopy
Design of a study to investigate the mechanisms of obstructive sleep apnoea by means of drug-induced sleep endoscopy
- Publication Year :
- 2019
-
Abstract
- Background Obstructive sleep apnoea (OSA) is an independent risk factor of hypertension and cardiovascular diseases. Recurrent episodes of upper airways collapse during sleep causing blood oxygen desaturation, hypercapnia, and micro-arousals, are known to activate the sympathetic nervous system (SNS). However, whether changes in the renin-angiotensin-aldosterone system and endothelial activation also occur remains contentious. Methods Based on routine use of drug-induced sleep endoscopy (DISE) for the work-up of OSA patients in our centre, we designed a prospective study to investigate the haemodynamic and humoral changes occurring during the apnoeic episodes reproduced in vivo in the course of DISE. Specifically, plasma aldosterone concentration and renin activity, C-terminal fragment of proendothelin-1, as a marker of endothelial damage, and free plasma catecholamines, will be measured at fixed times during DISE. The activity of catechol-O-methyltransferase (COMT), a key catecholamine-inactivating enzyme that has been scantly investigated thus far owing to the lack of commercially available kits, will be also determined by a newly developed high performance liquid chromatography method, which is herein described. Results and conclusions The aim of this study is to provide novel information on the haemodynamic, hormonal, and SNS changes, and also on COMT activity modification concomitantly occurring during apnoea, thus contributing substantively to the understanding of the pathophysiology of OSA.
- Subjects :
- Adult
Male
Sympathetic nervous system
medicine.medical_specialty
obstructive sleep apnoea
catechol-O-methyltransferase
Clinical Biochemistry
Hemodynamics
Pilot Projects
030204 cardiovascular system & hematology
Catechol O-Methyltransferase
Plasma renin activity
Endothelial activation
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Catecholamines
Internal medicine
Renin–angiotensin system
Renin
medicine
Humans
030212 general & internal medicine
Prospective Studies
drug-induced sleep endoscopy
endothelin-1
renin-angiotensin-aldosterone system
sympathetic nervous system
Protein Precursors
Aldosterone
Sleep Apnea, Obstructive
Catechol-O-methyl transferase
business.industry
Biochemistry (medical)
Endoscopy
General Medicine
medicine.anatomical_structure
chemistry
Research Design
Cardiology
medicine.symptom
business
Sleep
Hypercapnia
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....2a468baa1f75ca744b7b76ca58c7097e