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HLA-Matched Allogeneic iPS Cells-Derived RPE Transplantation for Macular Degeneration
- Source :
- Journal of Clinical Medicine, Volume 9, Issue 7, Journal of Clinical Medicine, Vol 9, Iss 2217, p 2217 (2020)
- Publication Year :
- 2020
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2020.
-
Abstract
- Immune attacks are key issues for cell transplantation. To assess the safety and the immune reactions after iPS cells-derived retinal pigment epithelium (iPS-RPE) transplantation, we transplanted HLA homozygote iPS-RPE cells established at an iPS bank in HLA-matched patients with exudative age-related macular degeneration. In addition, local steroids without immunosuppressive medications were administered. We monitored immune rejections by routine ocular examinations as well as by lymphocytes-graft cells immune reaction (LGIR) tests using graft RPE and the patient&rsquo<br />s blood cells. In all five of the cases that underwent iPS-RPE transplantation, the presence of graft cells was indicated by clumps or an area of increased pigmentation at 6 months, which became stable with no further abnormal growth in the graft during the 1-year observation period. Adverse events observed included corneal erosion, epiretinal membrane, retinal edema due to epiretinal membrane, elevated intraocular pressure, endophthalmitis, and mild immune rejection in the eye. In the one case exhibiting positive LGIR tests along with a slight fluid recurrence, we administrated local steroid therapy that subsequently resolved the suspected immune attacks. Although the cell delivery strategy must be further optimized, the present results suggest that it is possible to achieve stable survival and safety of iPS-RPE cell transplantation for a year.
- Subjects :
- medicine.medical_specialty
retina
macular degeneration
lcsh:Medicine
Human leukocyte antigen
Article
03 medical and health sciences
0302 clinical medicine
Immune system
Endophthalmitis
Ophthalmology
medicine
030304 developmental biology
0303 health sciences
Retina
Retinal pigment epithelium
immune reactions
business.industry
lcsh:R
General Medicine
Macular degeneration
medicine.disease
eye diseases
Transplantation
HLA
iPS cells
medicine.anatomical_structure
surgical procedures, operative
sense organs
Epiretinal membrane
business
030217 neurology & neurosurgery
transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 20770383
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....2a621145b13c7e577c731ad5424fb719
- Full Text :
- https://doi.org/10.3390/jcm9072217